Gene interactions and pathways from curated databases and text-mining

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IL12B — IL1R1

Text-mined interactions from Literome

Joosten et al., Ann Rheum Dis 2000 (Acute Disease...) : Enhancement of IL10 and IL1Ra by anti-IL12 was confirmed in a tissue chamber model with SCW induced inflammation
Chieppa et al., J Immunol 2003 (Inflammation) : MUC III ( a partially purified mucin ), biglycan ( a purified complex proteoglycan ), and mannosylated lipoarabinomannan from Mycobacterium tuberculosis affected cytokine production with high IL-10, IL-1R antagonist, IL-1R type II, and inhibition of IL-12
Doisne et al., J Immunol 2011 : In this study, we show that the concomitant presence of IL-1 and IL-23 is crucial to induce a rapid and sustained IL-17A/F and IL-22 response by these cells that requires TCR-CD1d interaction and partly relies on IL-23 mediated upregulation of IL-23R and IL-1R1 expression