UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to GNB2L1

GNB2L1 — TCEB1

Pathways - manually collected, often from reviews:

NCI Pathway Database Hypoxic and oxygen homeostasis regulation of HIF-1-alpha: HIF1A (HIF1A) → HIF1A/RACK1/Elongin B/Elongin C complex (GNB2L1-TCEB2-TCEB1-HIF1A) (modification, collaborate)
Isaacs et al., J Biol Chem 2002, Liu et al., Mol Cell 2007, Gradin et al., Mol Cell Biol 1996
Evidence: mutant phenotype, physical interaction
NCI Pathway Database Hypoxic and oxygen homeostasis regulation of HIF-1-alpha: HIF1A (HIF1A) → RACK1/Elongin B/Elongin C complex (GNB2L1-TCEB2-TCEB1) (modification, collaborate)
Isaacs et al., J Biol Chem 2002, Liu et al., Mol Cell 2007, Gradin et al., Mol Cell Biol 1996
Evidence: mutant phenotype, physical interaction
NCI Pathway Database Hypoxic and oxygen homeostasis regulation of HIF-1-alpha: HIF1A/Hsp90 complex (HIF1A-HSP90AA1) → HIF1A/RACK1/Elongin B/Elongin C complex (GNB2L1-TCEB2-TCEB1-HIF1A) (modification, collaborate)
Isaacs et al., J Biol Chem 2002, Liu et al., Mol Cell 2007, Gradin et al., Mol Cell Biol 1996
Evidence: mutant phenotype, physical interaction
NCI Pathway Database Hypoxic and oxygen homeostasis regulation of HIF-1-alpha: HIF1A/Hsp90 complex (HIF1A-HSP90AA1) → RACK1/Elongin B/Elongin C complex (GNB2L1-TCEB2-TCEB1) (modification, collaborate)
Isaacs et al., J Biol Chem 2002, Liu et al., Mol Cell 2007, Gradin et al., Mol Cell Biol 1996
Evidence: mutant phenotype, physical interaction
NCI Pathway Database Hypoxic and oxygen homeostasis regulation of HIF-1-alpha: Hsp90 (HSP90AA1) → HIF1A/RACK1/Elongin B/Elongin C complex (GNB2L1-TCEB2-TCEB1-HIF1A) (modification, collaborate)
Isaacs et al., J Biol Chem 2002, Liu et al., Mol Cell 2007, Gradin et al., Mol Cell Biol 1996
Evidence: mutant phenotype, physical interaction
NCI Pathway Database Hypoxic and oxygen homeostasis regulation of HIF-1-alpha: Hsp90 (HSP90AA1) → RACK1/Elongin B/Elongin C complex (GNB2L1-TCEB2-TCEB1) (modification, collaborate)
Isaacs et al., J Biol Chem 2002, Liu et al., Mol Cell 2007, Gradin et al., Mol Cell Biol 1996
Evidence: mutant phenotype, physical interaction
NCI Pathway Database Hypoxic and oxygen homeostasis regulation of HIF-1-alpha: HIF1A/RACK1/Elongin B/Elongin C complex (GNB2L1-TCEB2-TCEB1-HIF1A) → RACK1/Elongin B/Elongin C complex (GNB2L1-TCEB2-TCEB1) (modification, collaborate)
Isaacs et al., J Biol Chem 2002, Liu et al., Mol Cell 2007, Gradin et al., Mol Cell Biol 1996
Evidence: mutant phenotype, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

IRef Biogrid Interaction: GNB2L1 — TCEB1 (physical association, affinity chromatography technology) Subauste et al., Cancer Biol Ther 2009 *
IRef Biogrid Interaction: GNB2L1 — TCEB1 (physical association, affinity chromatography technology) Liu et al., Mol Cell 2007
IRef Biogrid Interaction: GNB2L1 — TCEB1 (direct interaction, pull down) Liu et al., Mol Cell 2007