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EGF — MMP14
Text-mined interactions from Literome
Reddy et al., Int J Cancer 1999
(Breast Neoplasms...) :
In contrast, when SKBR-3 cells were exposed to MEK inhibitor ( PD 98059 ) or MAPK inhibitors ( Apigenin or MAPK antisense phosphorothioate oligodeoxynucleotides ),
EGF induced cell proliferation,
MMP-9 induction and invasion through reconstituted basement membrane were significantly reduced
Sundareshan et al., Prostate 1999
(Adenocarcinoma...) :
Induction of the
MMP , matrilysin, by
epidermal growth factor (EGF) was investigated in a human prostate cancer cell line
Huang et al., Br J Pharmacol 1999
(Neoplasm Metastasis) :
8. This study demonstrates that the inhibitory effects of Lu and Qu, and the stimulatory
effects of
EGF , on tumour cell proliferation, cellular protein phosphorylation, and
MMP secretion may be mediated at least partly through EGFR
Domeij et al., Eur J Oral Sci 2002
(MAP Kinase Signaling System) :
In addition,
MMP-1 and MMP-3 production,
induced by IL-1beta, TNFalpha or
EGF , was strongly reduced by the presence of the glucocorticoid dexamethasone
Van Meter et al., Neuro Oncol 2004
(Glioma) :
Induction of
membrane-type-1 matrix metalloproteinase by
epidermal growth factor mediated signaling in gliomas ...
EGF stimulation of glioma cell lines
resulted in a 2- to 4-fold increase in
MT1-MMP mRNA levels ... Furthermore, the
MT1-MMP induction by
EGF was prevented by pretreatment with the EGFR-specific tyrphostin inhibitor AG1478 ... Similarly, treatment with the phosphatidylinositol 3-kinase inhibitor LY294002 prevented the
induction of
MT1-MMP protein by
EGF stimulation
Vesey et al., Kidney Int 2005
(Calcium Signaling...) :
These responses which are dependent on its protease activity appear not to be mediated by PAR-1 activation, the autocrine action of thrombin induced TGF-beta1 secretion,
MMP activation, or
EGF receptor
transactivation
Ahmed et al., Am J Physiol Cell Physiol 2006
(Cell Transformation, Neoplastic) :
EGF withdrawal resulted in a more epithelial morphology and reversal of the
EGF induced activation of signaling pathways and
pro-MMP activity
Cowden Dahl et al., Mol Cancer Res 2007
(Neoplasm Invasiveness...) :
Additionally, inhibition of PEA3 expression via short interfering RNA reduced the
EGF induction of MMP-9 and
MMP-14 gene expression by 92 % and 50 %, respectively, and impaired EGF stimulated tumor cell invasion
Yu et al., Cytotechnology 2009
:
Matrine significantly reduced the invasion,
MMP-9/MMP-2 activation , Akt phosphorylation, nuclear factor kappaB p-65 expression and DNA binding activity, and mRNA levels of MMP-9, MMP-2,
EGF and VEGFR1 in MDA-MB-231 cells
Zhang et al., Int J Gynecol Cancer 2009
(Carcinoma...) :
We showed here that
EGF induced the expression of
MT1-MMP and inhibited the expression of MMP-2 at both the mRNA and protein levels ... Our results suggest that
EGF receptor
up-regulated the expression of
MT1-MMP and down-regulated the synthesis of MMP-2 through the mitogen activated protein kinase/extracellular signal regulated kinase pathway while concomitantly transmitting a mild positive regulatory signal to the expression of MMP-2 via the PI3-K/AKT pathway in SiHa cells
Ouyang et al., Cancer Res 2010
:
This difference in the activation patterns of
MT1-MMP and Src in
response to
EGF is further confirmed using an optimized MT1-MMP biosensor capable of being rapidly cleaved by MT1-MMP
Pan et al., Invest Ophthalmol Vis Sci 2011
:
Hypertonicity induced
EGF receptor (EGFR) transactivation was
suppressed by preincubating HCECs with capsazepine, matrix metalloproteinase 1 (MMP1) inhibitor TIMP-1, broad-spectrum
MMP inhibitor GM 6001, heparin bound (HB)-EGF inhibitor CRM 197, or EGFR inhibitor AG 1478
Hwang et al., Mol Nutr Food Res 2011
(Fibrosarcoma...) :
Capsaicin decreased the
EGF induced expression of MMP-9,
MMP-2 , and MT1-MMP, but did not alter TIMP-1 and TIMP-2 levels
Ueda et al., Int J Cancer 1997
(Carcinoma, Squamous Cell...) :
We investigated the
effects of
epidermal growth factor (EGF) and transforming growth factor (TGF)-alpha on migration, invasion and
matrix metalloproteinase ( MMP ) expression of uterine cervical-carcinoma SKG-IIIb cells, and whether these growth factors affect pyrimidine-nucleoside-phosphorylase ( PyNPase ) activity and 5'-deoxy-5-fluorouridine ( 5'-dFUrd ) sensitivity of tumor cells