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EGF — ERF
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
ERF
→
EGF
(increases)
Olsen et al., Cell 2006*
Evidence: We have detected 6,600 phosphorylation sites on 2,244 proteins and have determined their temporal dynamics after stimulating HeLa cells with epidermal growth factor (EGF) and recorded them in the Phosida database
Text-mined interactions from Literome
Chen et al., Zhonghua Wai Ke Za Zhi 2004
(Breast Neoplasms...) :
EGF could significantly
induce the expression of
pERK1/2
Ikari et al., Biochem Biophys Res Commun 2009
:
EGF increased
p-ERK1/2 levels, which were inhibited by U0126, a MEK inhibitor
Kim et al., Aging Cell 2012
:
In addition,
epidermal growth factor stimulation
induced p-ERK1/2 nuclear translocation and Elk-1 phosphorylation were severely impaired by Sp1 depletion in young HDFs ; Sp1 overexpression restored the nuclear translocation of p-ERK1/2 in senescent HDFs