◀ Back to BMP2
BMP2 — PIK3R1
Text-mined interactions from Literome
Ghosh-Choudhury et al., J Biol Chem 2003
:
Phosphatidylinositol 3-kinase regulates bone morphogenetic protein-2 (BMP-2) induced myocyte enhancer factor 2A-dependent transcription of
BMP-2 gene in cardiomyocyte precursor cells
Ghosh-Choudhury et al., J Biol Chem 2007
(MAP Kinase Signaling System) :
Expression of dominant negative
PI3K and PTEN, an inhibitor of PI3K signaling, significantly
attenuated lovastatin induced transcription of
BMP-2
Lee et al., Int Immunopharmacol 2008
:
Interestingly, emodin induced the activation of phosphatidylinositol 3-kinase (PI3K), Akt and mitogen activated protein ( MAP ) kinases, but those inductions by emodin were completely inhibited by the PI3K inhibitor, LY294002, suggesting that the up-regulation of
BMP-2 by emodin could be
mediated through the activation of both Akt and MAP kinases by activating
PI3K
Fong et al., J Cell Physiol 2008
(Chondrosarcoma) :
Taken together, these results suggest that the
BMP-2 acts through
PI3K/Akt , which in turn activates IKKalpha/beta and NF-kappaB, resulting in the activations of beta1 integrin and contributing the migration of human chondrosarcoma cells
Graham et al., Prostate 2009
(Neoplasm Metastasis...) :
PI3K/Akt dependent transcriptional regulation and activation of
BMP-2-Smad signaling by NF-kappaB in metastatic prostate cancer cells ... Selective inhibition of
PI3K/Akt suppressed the NF-kappaB induced
BMP-2 promoter activity
Mandal et al., Endocrinology 2009
:
Inhibition of
PI3K/Akt signaling
blocked the binding of Smads 1/5 to the CSF-1
BMP-responsive element present in the CSF-1 promoter, resulting in attenuation of Smad dependent CSF-1 transcription
Liu et al., Biochem Biophys Res Commun 2013
:
Furthermore, in the presence of exogenous
BMP-2 ,
PI3K and Akt inhibitors
blocked Runx2 and osteocalcin expression, although BMP-2 did not activate Akt
Ueki et al., Glia 2013
:
Interestingly,
BMP/Smad1/5/8 activation downstream of
PI3K/AKT signaling was also necessary for robust Müller glial proliferation, though activation of BMP/Smad1/5/8 signaling alone failed to stimulate their proliferation