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BCL3 — MMP1
Text-mined interactions from Literome
Elliott et al., Arthritis Rheum 2002
:
To define the
role of
Bcl-3 , a member of the inhibitor of nuclear factor kappaB (NF-kappaB) family and a known regulator of NF-kappaB, in interleukin-1 (IL-1) induced
matrix metalloproteinase 1 (MMP-1) transcription in chondrocytes and synovial fibroblasts ... Exogenous expression of
Bcl-3 in SW-1353 cells
activated MMP-1 transcription ... Endogenous
Bcl-3 expression was
required for IL-1beta induction of
MMP-1 gene expression ...
Bcl-3 also
activated MMP-1 transcription in primary synovial fibroblasts
Elliott et al., Arthritis Res Ther 2003
(Bone Neoplasms...) :
Overexpression of
Bcl-3 increased
MMP-1 , but not MMP-13, mRNA levels
Lecoeur et al., Cell death & disease 2012
:
Pharmacologic inhibitors of the permeability transition pore, Bax/Bak inhibitors, and recombinant Bcl-2 and
Bcl-XL proteins do not
reduce Tat induced
MMP
Arbab et al., Evidence-based complementary and alternative medicine : eCAM 2012
:
We found that dentatin mediated accumulation of reactive oxygen species ( ROS ) and downregulated expression levels of antiapoptotic molecules ( Bcl-2,
Bcl-xL , and Survivin ),
leading to disruption of mitochondrial
membrane potential ( MMP ) , cell membrane permeability, and release of cytochrome c from the mitochondria into the cytosol