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ANGPT2 — SERPINE1
Text-mined interactions from Literome
Gesualdo et al., Kidney Int 1999
(Fibrosis...) :
PAI-1 induction by
Ang II in endothelial cells seems to be mediated by Ang IV via a receptor that is different from Ang II type 1 and 2 receptors ( AT1 and AT2 ) ... Our results demonstrate that
Ang II stimulates
PAI-1 mRNA expression and the production of its protein in human proximal tubular cells
Brown et al., J Clin Endocrinol Metab 2000
(Hyperaldosteronism) :
Taken together, these data support the hypothesis that aldosterone modulates the
effect of
Ang II on
PAI-1 expression in vitro and in vivo in humans
Motojima et al., Biochem J 2000
:
We studied this region to determine the transcription factor ( s ) that mediates
Ang-II induced transcriptional activation of the
PAI-1 gene ... Various double stranded decoy oligodeoxynucleotides ( ODNs ) corresponding to various sequences in the proximal promoter region were transfected to mesangial cells to examine the effects on
Ang-II induced
PAI-1 mRNA expression ... Transfection with the full-length decoy ( bp -87 to -45, D-P-ODN ) markedly attenuated
Ang-II induced
PAI-1 mRNA expression by up to 70 %
Chen et al., Arterioscler Thromb Vasc Biol 2000
:
In vitro, angiotensin (Ang) I,
Ang II , and angiotensin Arg(2)-Phe ( 8 ) ( Ang III ) were potent agonists of PAI-1 mRNA expression in rat aortic smooth muscle cells ( RASMCs ), and stimulation of
PAI-1 by these peptides was
blocked by the AT(1) antagonist candesartan ... In neonatal rat cardiomyocytes,
Ang II increased
PAI-1 mRNA expression by 4-fold ( P < 0.01 ), and this response was completely blocked by AT(1) receptor antagonism ... These results demonstrate a role for the AT(1) receptor in mediating the
effects of
Ang II on aortic and cardiac
PAI-1 gene expression
Skurk et al., Hypertension 2001
:
The aim of this study was to investigate the
role of
angiotensin (Ang) II and its degradation products for
PAI-1 release from human adipose cells
Ahn et al., Diabetologia 2001
:
This study tested the hypothesis that hyperglycaemia and
Ang II stimulate
PAI-1 gene expression through activator protein-1 (AP-1) binding sites ... This study shows that high glucose and
Ang II stimulate
PAI-1 expression through AP-1 binding sites
Yoshida et al., Thromb Res 2002
:
Ang II increased
PAI-1 and tissue plasminogen activator (t-PA) release, while its metabolite angiotensin- ( 1-7 ) ( Ang- ( 1-7 ) ) amino acid fragment decreased them
Sawathiparnich et al., J Clin Endocrinol Metab 2003
:
This study evidences an interactive
effect of endogenous
Ang II and aldosterone on
PAI-1 production in humans
Weisberg et al., Arterioscler Thromb Vasc Biol 2005
(Aortic Diseases...) :
Ang II increased aortic mRNA expression of
PAI-1 , collagen I, collagen III, fibronectin, osteopontin, monocyte chemoattractant protein-1, and F4/80 ; PAI-039 significantly decreased the Ang II-induced increase in aortic osteopontin expression at 8 weeks
Brown et al., Kidney Int 2007
:
We measured
effects of
Ang II or norepinephrine on
PAI-1 expression in wild type ( WT ) and Ang type-1a receptor knockout mice ( AT ( 1a ) -/- ) in the presence or absence of the non-specific AT(1) antagonist losartan ...
Ang II stimulated
PAI-1 expression in the heart, aorta, and kidney and markedly in the liver of WT mice ... We conclude that
Ang II stimulates
PAI-1 expression in part through the AT ( 1b ) receptor in the kidney and liver
Fintha et al., Acta Physiol Hung 2007
:
Ang II but not Ang IV
activates the
PAI-1 promoter in renal proximal tubular cells and this effect is mediated by tyrosine kinases
Liu et al., Acta Pharmacol Sin 2008
:
atRA also decreased the prolonged
effect of
Ang II on
PAI-1 expression
Luther et al., Endocrinology 2009
:
Ang II increased
PAI-1 ( P = 0.01 ) expression in the aorta of AS ( -/- ) as well as WT mice ... Endogenous aldosterone contributes to the acute stimulatory
effect of
Ang II on
PAI-1 and ppET-1 mRNA expression in the heart ; renin activity correlates with basal profibrotic gene expression in the kidney
Yu et al., Endocrinology 1996
(Hypertension) :
Although
PAI-1 gene expression was also
stimulated by
Ang II in neuronal cultures of SH rat brain, two differences between WKY and SH rat brain neurons were observed : 1 ) the level of Ang II stimulation in SH rat neurons was 50 % of that in WKY rat neurons ; and 2 ) Ang II stimulation of c-fos was 2.4-fold higher in SH neurons than in WKY neurons, but c-fos antisense oligonucleotide did not attenuate the stimulatory action of Ang II on PAI-1 mRNA in SH neurons
Kagami et al., Kidney Int 1997
:
Induction of PAI-1 at four hours was not altered but the prolonged
effect of
Ang II on
PAI-1 protein synthesis was markedly diminished
Shihab et al., Kidney Int 1997
(Kidney Diseases) :
Similarly,
Ang II blockade
resulted in decreased expression of TGF-beta1 and
PAI-1 by Northern and ELISA
Kim et al., Arterioscler Thromb Vasc Biol 1997
(Coronary Disease...) :
It has been shown that Ang II modulates fibrinolysis, that is,
Ang II increases plasminogen activator inhibitor-1 ( PAI-1 ) mRNA and plasma
PAI-1 levels in vitro and in vivo