◀ Back to NOTCH4
ITCH — NOTCH4
Text-mined interactions from Literome
Matesic et al., Hum Mol Genet 2006
(Autoimmune Diseases...) :
Since Notch proteins have many important functions in the immune system, we determined whether
Itch regulates
Notch signaling in vivo
Chastagner et al., PloS one 2008
:
AIP4/Itch regulates
Notch receptor degradation in the absence of ligand ... Using Itch-/- fibroblasts expressing the Notch1 receptor, we show that
Itch is not
necessary for
Notch activation, but rather for controlling the degradation of Notch in the absence of ligand