◀ Back to CREB5
CREB5 — MSK32
Text-mined interactions from Literome
Arthur et al., FEBS Lett 2000
:
MSK1 is
required for
CREB phosphorylation in response to mitogens in mouse embryonic stem cells ... Thus
MSK1 is
required for
CREB and ATF1 phosphorylation after mitogenic stimulation of ES cells
Mayo et al., J Biol Chem 2001
:
p38
MAPK/MSK-1 and protein kinase C/p90RSK pathways
mediate CREB phosphorylation
Arthur et al., J Neurosci 2004
:
However, expression of a selective inhibitory
MSK1 mutant markedly
attenuated BDNF stimulated
CREB phosphorylation and CREB mediated transcription
Markou et al., J Mol Cell Cardiol 2004
(Cardiomegaly) :
Phenylephrine
induces activation of
CREB in adult rat cardiac myocytes through
MSK1 and PKA signaling pathways
Darragh et al., Biochem J 2005
(MAP Kinase Signaling System) :
MSK ( mitogen- and stress activated protein kinase ) 1 and
MSK2 are kinases activated downstream of either the ERK ( extracellular-signal regulated kinase ) 1/2 or p38 MAPK ( mitogen activated protein kinase ) pathways in vivo and are
required for the phosphorylation of
CREB ( cAMP response element binding protein ) and histone H3
Delghandi et al., Cell Signal 2005
:
The p38 mediated activation of
CREB was
inhibited by dominant negative mutants of
MSK-1 and by the PKA/MSK-1 inhibitor H89, but not by dominant negative mutants of MSK-2/RSK-B and MAPKAPK2
Funding et al., J Invest Dermatol 2007
(Psoriasis) :
This study demonstrate for the first time the expression of
MSK2 in keratinocytes and increased MSK2 and
CREB activation in lesional psoriatic skin
Kaiser et al., Eur J Immunol 2007
:
MSK regulate TCR induced
CREB phosphorylation but not immediate early gene transcription ... This correlated to a reduction in the TCR induced up-regulation of the IL-2 receptor CD25 and a
requirement for
MSK in IL-2 induced
CREB phosphorylation
Kawaguchi et al., Am J Physiol Lung Cell Mol Physiol 2009
:
Moreover, transfection of the cells with siRNAs targeting
MSK1 inhibited
activation of
CREB , and the siRNAs targeting MSK1 and CREB blocked expression of IL-11
Ronkina et al., Nucleic Acids Res 2011
(MAP Kinase Signaling System) :
Stress activated p38a MAP kinase is implicated in transcriptional regulation of IEGs via
MSK mediated
CREB phosphorylation
Deak et al., EMBO J 1998
:
These findings, together with other observations, suggest that
MSK1 may
mediate the growth-factor and stress induced activation of
CREB