Duronio et al., Genes Dev 1995
:
Instead, cyclin E expression activates E2F in the CNS
Chiarugi et al., Cell Mol Biol Res 1994
:
Notably, both of the two giant regulators of checkpoint 1 ( i.e., p105RB [ retinoblastoma oncosuppressor encoded protein ] and p53 dependent WAF1/CIP1 ) are influenced by or influence G1 cyclins : cyclin E/cdk2 kinase complexes hyperphosphorylate p105RB, induce E2F release, and free G1 exit