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CDC42 — TCF23
Text-mined interactions from Literome
Meimoun et al., Mol Biol Cell 2000
:
Here we report that SCF (
CDC4 ), a recently characterized protein complex that acts in conjunction with the ubiquitin conjugating enzyme Cdc34 to degrade cell cycle regulators, is also
necessary for the degradation of the
transcription factor Gcn4. Degradation of Gcn4 occurs throughout the cell cycle, whereas degradation of the known cell cycle substrates of Cdc34/SCF(CDC4) is cell cycle regulated
Mehta et al., J Biol Chem 2009
:
In T cells, SLAT expression regulates the development of T helper cells through
Cdc42- and Rac1 mediated
activation of the NF-AT
transcription factor
Chen et al., BMC systems biology 2009
:
The regulated action for four selected cytokinesis related genes ( BUD4, CHS2, IQG1, and CDC5 ) belongs to the M-phase or M/G1 phase, consistent with the empirical observations that in S. cerevisiae, the Mcm1-Ndd1-Fkh2
transcription factor complex can
regulate expression of the cytokinesis related genes BUD4, CHS2, IQG1, and
CDC5
Acosta et al., Mol Biol Cell 2011
:
In contrast,
CDC5 overexpression
leads to premature induction of the Ndt80
transcription factor , which drives the expression of genes required for meiotic divisions, including CLB1
Wan et al., Biochem Biophys Res Commun 2013
(Mechanotransduction, Cellular) :
In contrast, constitutively active Rac1 and
Cdc42 mutants
caused a significant enhancement of
TCF/LEF activity ... Moreover, activation of Rac1 and
Cdc42 increased the basal level of
TCF/LEF activity, while their inhibition decreased the basal level
Cross et al., Mol Cell Biol 1994
:
It has been proposed that positive feedback operates via
Cln/Cdc28 activation of the Swi4/Swi6
transcription factor , leading to CLN1 and CLN2 transcription due to Swi4 binding to specific sites ( SCBs ) in the CLN1 and CLN2 promoters