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MSC — STAT3
Text-mined interactions from Literome
Wang et al., J Mol Cell Cardiol 2007
:
STAT3 deficiency
resulted in decreased
MSC production of VEGF ... However, inhibition of p38 MAPK blocked release of VEGF in STAT3KO MSCs. MSCs are a potent source of VEGF, the production of which is mediated by STAT3 under normoxia partly ; however, following hypoxia or TNF exposure,
MSC release of VEGF is
mediated by both
STAT3 and p38 MAPK
Sasser et al., FASEB J 2007
(Breast Neoplasms) :
All ERalpha positive breast tumor cell lines displayed low basal activation of signal transducer and activator of transcription 3 ( STAT3 ) until exposed to
MSC , which
induced chronic phosphorylation of
STAT3 on tyrosine-705 ... Paracrine IL-6 was found to be the principal mediator of STAT3 phosphorylation in coculture studies, and
MSC induction of
STAT3 phosphorylation was lost when IL-6 was depleted from MSC conditioned media or the IL-6 receptor was blocked on tumor cells