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IL9 — STAT3

Text-mined interactions from Literome

Demoulin et al., Cytokines Cell Mol Ther 1998 : IL-2, IL-7, IL-9 and IL-15 activate STAT3 and STAT5, in contrast to IL-4, which activates STAT6
O'Brien et al., J Biol Chem 1999 : STAT3 activation in stromal/osteoblastic cells is required for induction of the receptor activator of NF-kappaB ligand and stimulation of osteoclastogenesis by gp130 utilizing cytokines or interleukin-1 but not 1,25-dihydroxyvitamin D3 or parathyroid hormone
Demoulin et al., Cell Growth Differ 2001 (Lymphoma...) : Using mutated IL-9 receptors, we showed that inhibition of proliferation was correlated with STAT1 and STAT3 activation by IL-9 and induction of the cell cycle inhibitor p19/ink4d, a STAT3 target gene
Yamasaki et al., PloS one 2010 : IL-9 induced rapid STAT3 activation in primary ASM cells that was not observed in case of STAT6 or STAT5 ... Disruption of STAT3 activity with SH2 domain binding inhibitory peptide results in significant reduction of IL-9 mediated CCL11 promoter activity
Ozawa et al., Journal of ophthalmology 2011 : In innate chorioretinal inflammation, interleukin-6 family ligands induce STAT3 activation in photoreceptors, which causes UPS mediated excessive degradation of the visual substance, rhodopsin
Zhu et al., J Biol Chem 1997 : Deletion of this region significantly impaired IL-9 induced cell growth, activation of JAK kinases, insulin receptor substrate-2, and STAT3 and expression of early response genes ... A point mutation changing YLPQ into YLPA greatly reduced IL-9 induced activation of STAT3 and expression of c-myc but did not affect cell proliferation