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FGF9 — STAT3

Text-mined interactions from Literome

Ishikawa et al., Oncogene 2005 (Multiple Myeloma...) : Furthermore, the FGF induced activation of ERK 1/2 contributed to the serine phosphorylation of STAT 3 , suggesting that the signaling crosstalk between the cytokine receptor, IL-6 receptor alpha/gp 130 and the growth factor receptor tyrosine kinase, FGFR 3
Li et al., Clin Cancer Res 2006 (Carcinoma, Hepatocellular...) : In mice bearing orthotopically implanted HCCLM3, STAT3 inhibition following therapeutic treatment with STAT3 ASO reduced circulating vascular endothelial growth factor and basic fibroblast growth factor , decreased intratumor CD34 positive microvessel density, intrahepatic and intraperitoneal transmission, and lung metastasis
Krejci et al., J Cell Sci 2008 : However, as demonstrated by western blotting with phosphorylation-specific antibodies, imaging of STAT nuclear translocation, STAT transcription factor assays and STAT luciferase reporter assays, FGF does not activate STAT1 or STAT3 in RCS chondrocytes, which nevertheless respond to a FGF stimulus with potent growth arrest
Krejci et al., Cell Signal 2009 : Despite the accumulation, both endogenous and cytokine induced activation of STAT1 and STAT3 is impaired by FGF , as demonstrated by imaging of active STAT nuclear translocation and analyses of STAT activatory phosphorylation and transcriptional activation
Bhatnagar et al., J Biol Chem 2009 : In contrast, FGF-19 increased the activity of STAT3 , an inhibitor of SREBP-1c expression and decreased the expression of peroxisome proliferator activated receptor-gamma coactivator-1beta ( PGC-1beta ), an activator of SREBP-1c activity