Gene interactions and pathways from curated databases and text-mining

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RYR2 — TRDN

Pathways - manually collected, often from reviews:

  • Reactome Reaction: RYR2 → TRDN (indirect_complex)

Text-mined interactions from Literome

Kalyanasundaram et al., Am J Physiol Heart Circ Physiol 2012 (Calcium Signaling...) : We propose that poor interaction between CASQ2 ( D307H ) and triadin 1 could affect ryanodine receptor 2 stability, thereby increasing susceptibility to delayed afterdepolarizations and triggered arrhythmic activity
Dulhunty et al., Acta Physiol Scand 1996 : Effects of phosphorylation, calmodulin, triadin , calsequestrin and interactions with the alpha 1 subunit of the dihydropyridine receptor on ryanodine receptor activity are summarized
Ohkura et al., Biochemistry 1998 : These results suggest that triadin inhibits the RyR activity and that RyR is regulated by both triadin and calsequestrin, probably through an interaction between them