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IL10 — RELA

Text-mined interactions from Literome

Barcova et al., Pflugers Arch 1999 : Thus HIV-1 gp41 induced IL-10 up-regulation in monocytes may not involve NF-kappaB , MAPK, or PI 3-kinase activation, but rather may operate through activation of adenylate cyclase and pertussis-toxin-sensitive Gi/Go protein to effect p70 ( S6 ) -kinase activation
Takeda et al., Science 1999 (Limb Deformities, Congenital...) : In contrast, there was no impairment of NF-kappaB activation induced by either interleukin-1 or tumor necrosis factor-alpha in IKKalpha-deficient embryonic fibroblasts and thymocytes, indicating that IKKalpha is not essential for cytokine induced activation of NF-kappaB
Vig et al., J Biol Chem 1999 : Modulation of tumor necrosis factor and interleukin-1 dependent NF-kappaB activity by mPLK/IRAK
Bondeson et al., Proc Natl Acad Sci U S A 1999 (Arthritis, Rheumatoid...) : We found that the spontaneous production of tumor necrosis factor alpha and other pro-inflammatory cytokines is NF-kappaB dependent in rheumatoid synovial tissue, in contrast to the main anti-inflammatory mediators, like IL-10 and -11, and the IL-1 receptor antagonist
Li et al., J Exp Med 1999 : Accordingly, IKKbeta-deficient cells are defective in activation of IKK and NF-kappaB in response to either tumor necrosis factor alpha or interleukin 1
Seppänen et al., Oncol Res 1998 (Adenocarcinoma...) : In the present study, we have investigated the effects of interferons-alpha (IFN-alpha) and -gamma ( IFN-gamma ), interleukin-10 (IL-10) and -13 ( IL-13 ), transforming growth factor-beta1 ( TGF-beta1 ), granulocyte-macrophage colony stimulating factor ( GM-CSF ), and tumor necrosis factor-alpha (TNF-alpha) on cell proliferation and induction of transcription factors AP-1 and NF-kappaB in UM-EC-3 human endometrial adenocarcinoma cells and UT-OC-5 ovarian carcinoma cells in vitro ... In the present study, we have investigated the effects of interferons-alpha (IFN-alpha) and -gamma ( IFN-gamma ), interleukin-10 (IL-10) and -13 ( IL-13 ), transforming growth factor-beta1 ( TGF-beta1 ), granulocyte-macrophage colony stimulating factor ( GM-CSF ), and tumor necrosis factor-alpha (TNF-alpha) on cell proliferation and induction of transcription factors AP-1 and NF-kappaB in UM-EC-3 human endometrial adenocarcinoma cells and UT-OC-5 ovarian carcinoma cells in vitro
Hu et al., J Leukoc Biol 1999 : Anti-inflammatory cytokines, IL-10 , and transforming growth factor ( TGF ) -beta sequentially inhibited LPS- and cytokine induced microglial cell NF-kappaB activation, RANTES mRNA expression, and protein release
Yoshidome et al., Hepatology 1999 (Edema...) : The objective of the current study was to determine whether IL-10 could suppress hepatic ischemia/reperfusion induced NFkappaB activation and the ensuing inflammatory liver injury ... IL-10 suppressed NFkappaB activation as well as messenger RNA expression of tumor necrosis factor-alpha (TNF-alpha) and macrophage inflammatory protein-2 ( MIP-2 )
Greene et al., Biochim Biophys Acta 1999 : Interleukin-1 receptor associated kinase, IRAK, has been shown to activate NFkappaB in response to interleukin-1
Belt et al., Am J Obstet Gynecol 1999 : In this study we investigated the possible role of the nuclear transcription factor NF-kappaB in interleukin-1 signaling, leading to the expression of cyclooxygenase 2 and prostaglandin production in human myometrial cell cultures ... Stimulation of human myometrial cells with interleukin 1 leads to rapid activation of the transcription factor NF-kappaB , which is functionally linked to the expression of cyclooxygenase 2 messenger ribonucleic acid, protein, and prostaglandin synthesis
Egan et al., J Biol Chem 1999 : Inhibition of interleukin-1 stimulated NF-kappaB RelA/p65 phosphorylation by mesalamine is accompanied by decreased transcriptional activity ... Inhibition of interleukin-1 stimulated NF-kappaB RelA/p65 phosphorylation by mesalamine is accompanied by decreased transcriptional activity
Yoshidome et al., Am J Physiol 1999 (Hepatopulmonary Syndrome...) : Interleukin-10 inhibits pulmonary NF-kappaB activation and lung injury induced by hepatic ischemia-reperfusion ... The objective of the current study was to determine whether IL-10 could suppress pulmonary NF-kappaB activation and ensuing lung injury induced by hepatic ischemia-reperfusion
Sica et al., J Immunol 2000 (Fibrosarcoma...) : Autocrine production of IL-10 mediates defective IL-12 production and NF-kappa B activation in tumor associated macrophages
Sun et al., Nature 2000 : Activation of NF-kappaB by tumour-necrosis factor alpha and interleukin-1 was unaffected in the mutant mice
Iber et al., Arch Biochem Biophys 2000 : Suppression of CYP2C11 gene transcription by interleukin-1 mediated by NF-kappaB binding at the transcription start site
Raychaudhuri et al., Cytokine 2000 : IL-10 also inhibited TNF secretion and NF-kappa B activation induced by another stimulus, staphylococcal toxin
Vockerodt et al., Virology 2001 (Burkitt Lymphoma...) : Inhibition of LMP1 mediated NF kappa B activation by constitutive repressive I kappa B-alpha only marginally impaired IL-10 expression in BL2 cells, while SB2035080 at 5 microM ( a specific p38/SAPK2 inhibitor ) led to reduced IL-10 expression
Takeuchi et al., Antioxid Redox Signal 2000 : Thioredoxin inhibits tumor necrosis factor- or interleukin-1 induced NF-kappaB activation at a level upstream of NF-kappaB inducing kinase
Bachis et al., J Neurosci 2001 : IL-10 blocked both the glutamate mediated induction of caspase-3 as well as NF-kappaB DNA binding activity, suggesting that the neuroprotective properties of IL-10 may rely on its ability to block the activity of proapoptotic proteins
Dokka et al., Am J Physiol Lung Cell Mol Physiol 2001 : Although still controversial, IL-10 has been shown to inhibit NF-kappaB activation through a process that involves proteolytic degradation of inhibitory subunit IkappaB-alpha
Van Huffel et al., J Biol Chem 2001 : NF-kappaB activation induced by TNF and interleukin-1 is inhibited by overexpression of ABIN-2
Shames et al., J Surg Res 2001 : Exogenous IL-10 inhibits NF-kappaB in monocytes and thus attenuates TNF-alpha production ... We examined the role of endogenous IL-10 in the regulation of NF-kappaB activation and TNF-alpha production in human monocytes by cAMP
Fichorova et al., J Infect Dis 2001 (HIV Infections...) : Analysis of molecular and cellular components in cervicovaginal secretions, as well as results from in vitro activation of cervicovaginal epithelial cells and U1/HIV promonocytic cells, showed that multiple N-9 use can promote HIV-1 transmission through interleukin-1 mediated NF-kappaB activation, which leads to chemokine induced recruitment of HIV-1 host cells and increased HIV-1 replication in infected cells
Qian et al., J Biol Chem 2001 : IRAK mediated translocation of TRAF6 and TAB2 in the interleukin-1 induced activation of NFkappa B
Bradbury et al., Cancer Res 2001 : Recently, it also has been demonstrated that nonsteroidal anti-inflammatory agents inhibit tumor necrosis factor and interleukin-1 induced NF-kappaB activation and act as radiosensitizing agents
Haddad et al., Am J Respir Cell Mol Biol 2002 : Recombinant IL-10 blockaded LPS induced biosynthesis of IL-1beta and TNF-alpha and reduced NF-kappaB activation
Wright et al., Am J Physiol Heart Circ Physiol 2002 : However, interleukin-1beta and phorbol 12-myristate 13-acetate also activated NF-kappaB but did not evoke TNF-alpha expression, revealing that this factor is not sufficient for cytokine production
Ye et al., Neuroimmunomodulation 2001 : In subsequent studies, the effect of recombinant murine IL-10 on constitutive and inducible NFkappaB activity, IL-6 mRNA expression and IL-6 protein secretion by glia cultured from brains of adult and aged mice was determined
Kotake et al., Shock 2002 (Endotoxemia) : Gel-shift and immunohistochemical analyses indicated that the transcription factor NF-kappaB was deactivated after PBN treatment, suggesting that NF-kappaB deactivation is closely involved in IL-10 overexpression
Friedman et al., J Virol 2002 : We demonstrate here that the E3 region of Ad inhibits the activation of NF-kappa B induced by tumor necrosis factor alpha (TNF-alpha) and interleukin-1
Liacini et al., Matrix Biol 2002 (Osteoarthritis, Hip) : Inhibition of interleukin-1 stimulated MAP kinases, activating protein-1 (AP-1) and nuclear factor kappa B (NF-kappa B) transcription factors down-regulates matrix metalloproteinase gene expression in articular chondrocytes
Ward et al., Mol Cell Biochem 2002 (Acute Disease...) : IL-10 and IL-13 attenuate NF-kappaB activation by interfering with breakdown of IkappaBalpha, while SLPI likewise suppresses NF-kappaB activation, but by interfering with breakdown of IkappaBbeta
Raychaudhuri et al., Clin Immunol 2002 (Hypertension, Pulmonary) : However, mRNA expression was decreased compared to controls for NF-kappaB regulated genes, granulocyte macrophage colony stimulating factor, interleukin-6 , macrophage inflammatory protein-1alpha ( MIP-1alpha ), and vascular endothelial growth factor
Cogswell et al., J Biol Chem 2003 : Stimulation of cells with inflammatory cytokines such as tumor necrosis factor alpha or interleukin-1 induces the degradation of I kappa B, the inhibitor of NF-kappa B , allowing nuclear accumulation of NF-kappa B and regulation of specific gene expression
Ikeda et al., J Leukoc Biol 2002 : Furthermore, IL-10 suppressed lipopolysaccharide (LPS) induced NF-kappaB binding but not Sp-1
Park et al., DNA Cell Biol 2003 : The effects of increased SOCS-3 expression upon IL-10 regulation of NF-kappaB activation have not yet been demonstrated
Tapia et al., Free Radic Biol Med 2003 : It is concluded that T ( 3 ) -induced oxidative stress enhances the DNA binding activity of NF-kappaB and the NF-kappaB dependent expression of TNF-alpha and IL-10 genes
Jiang et al., J Biol Chem 2004 : Without ERK activation, interleukin-1beta induces only acute and transient NF-kappaB activation
Driessler et al., Clin Exp Immunol 2004 (Translocation, Genetic) : Molecular mechanisms of interleukin-10 mediated inhibition of NF-kappaB activity : a role for p50
Takada et al., J Biol Chem 2004 : PTD-p65-P1 suppressed NF-kappaB activation induced by lipopolysaccharide, interleukin-1 , okadaic acid, phorbol 12-myristate 13-acetate, H ( 2 ) O ( 2 ), and cigarette smoke condensate as well as that induced by TNF
Bhattacharyya et al., Blood 2004 : Notably, IL-10 mediated inhibition of NF-kappaB coincided with suppressed IkappaB kinase (IKK) activity in vitro ... Furthermore, IL-10 blocked inducible Akt phosphorylation, and inhibitors of phosphatidylinositol 3-kinase (PI3K) effectively suppressed the activation of Akt, IKK, and NF-kappaB
Hoentjen et al., Blood 2005 : Chromatin immunoprecipitation demonstrated enhanced NF-kappaB ( cRel, RelA ) binding to the IL-12p40 promoter in IL-10 ( -/- ) but not WT BMDCs. Interestingly, LPS induced STAT3 phosphorylation in WT but not IL-10 ( -/- ) BMDCs, a process blocked by IL-10 receptor blocking antibody
Shishodia et al., J Biol Chem 2004 (Inflammation...) : Guggulsterone suppressed DNA binding of NF-kappaB induced by tumor necrosis factor (TNF), phorbol ester, okadaic acid, cigarette smoke condensate, hydrogen peroxide, and interleukin-1
Kwon et al., Mol Cell Biol 2004 : Signaling molecule that interacts with mouse pelle-like kinase ( SIMPL ) is a signaling component required for tumor necrosis factor alpha (TNF-alpha) dependent but not interleukin-1 dependent NF-kappaB activation
Du et al., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2004 : NF-kappaB p65 activity in mesangial cells may be inhibited by IL-10 secreted by splenic lymphocytes from the oral immune tolerance rats
Ji et al., Ann Clin Lab Sci 2004 (Disease Models, Animal...) : The results showed that LPS elevated the production of TNF-alpha, IL-6, and IL-10 and enhanced NF-kappaB activation in rat intestine
Kokura et al., Cancer Lett 2005 (Adenocarcinoma...) : Recent papers indicate that NF-kappa B activation is inhibited by interleukin (IL)-10
Santiago-Lomelí et al., Life Sci 2005 (Chronic Disease...) : IL-10 did not have any effect on the signaling cascade of apoptosis but caused a significant increase in NF-kappaB activation
Feng et al., Mol Cell Biol 2005 : The LIM protein Ajuba influences interleukin-1 induced NF-kappaB activation by affecting the assembly and activity of the protein kinase Czeta/p62/TRAF6 signaling complex
Saraiva et al., J Immunol 2005 : In support of a function for this site, NF-kappaB p65/RelA was recruited to HSS-4.5 in vivo and its activation was required for optimal IL-10 gene expression in LPS stimulated macrophages
Qiu et al., Shock 2006 (Liver Failure...) : These results suggest that FN protected against GalN/LPS induced liver failure by a mechanism involving inhibition of NF-kappaB activation, which caused down-regulation of TNF-alpha and involved up-regulation of IL-10 , and elevation of Bcl-xL induced a blockage of apoptotic signals, by which apoptosis of hepatocytes caused by GalN/LPS was suppressed
Wang et al., Nat Immunol 2006 : Tumor necrosis factor receptor associated factor 6 ( TRAF6 ) is critical for mediating Toll-like receptor ( TLR ) -interleukin 1 receptor (IL-1R) signaling and subsequent activation of NF-kappaB and AP-1, transcriptional activators of innate immunity
LaVallie et al., J Biol Chem 2006 (Osteoarthritis) : Protein kinase Czeta is up-regulated in osteoarthritic cartilage and is required for activation of NF-kappaB by tumor necrosis factor and interleukin-1 in articular chondrocytes
Cao et al., J Biol Chem 2006 : Taken together, our studies demonstrate that NF-kappaB1 ( p50 ) homodimers can be transcriptional activators of IL-10
Zhang et al., Infect Immun 2006 (Actinobacillus Infections...) : Interleukin-10 inhibits gram-negative-microbe-specific human receptor activator of NF-kappaB ligand positive CD4+-Th1-cell associated alveolar bone loss in vivo
Wu et al., Can J Physiol Pharmacol 2006 (Asthma) : Montelukast prevents the decrease of interleukin-10 and inhibits NF-kappaB activation in inflammatory airway of asthmatic guinea pigs ... In the present study, the effects of montelukast on the level of IL-10 and on the activation of NF-kappaB in the inflammatory airway of asthmatic guinea pigs were investigated ... There was a significantly negative correlation between the level of IL-10 and the activation of NF-kappaB in lung tissues ( r = -0.488, p < 0.01 ) ... From all these findings we conclude that montelukast can prevent the decrease of IL-10 and inhibit the activation of NF-kappaB in inflammatory airway of asthmatic guinea pigs, which may be the new important mechanisms of montelukast 's anti-airway-inflammation effects in asthmatic guinea pigs
Komine et al., Mol Immunol 2007 (Periodontitis) : Con A low-affinity saliva Lf peptides, PR3 treated Lf preparation and two of four synthetic polypeptides induced the production of interleukin IL-6, monocyte chemoattractant protein-1 and IL-8, and the activation of NF-kappaB in human oral epithelial HSC-2 cells
Suzuki et al., Trends Immunol 2006 : Although each system seems to possess distinct activation mechanisms, interleukin-1 receptor associated kinase ( IRAK)-4 is essential for NF-kappaB activation in Toll-like receptor ( TLR ) and T-cell receptor ( TCR ) signaling pathways
Liu et al., Indian J Med Res 2006 (Myocardial Reperfusion Injury) : The suppression of proinflammatory cytokines expression may act by inhibiting NF-kB activation during I-R, but not by induction of IL-10
Wullaert et al., J Biol Chem 2007 : Similar to the other ABINs, ABIN-3 binds to A20 and inhibits NF-kappaB activation induced by tumor necrosis factor, interleukin-1 , and 12-O-tetradecanoylphorbol-13-acetate
Ahn et al., J Biol Chem 2007 : Besides TNF, gamma-tocotrienol also abolished NF-kappaB activation induced by phorbol myristate acetate, okadaic acid, lipopolysaccharide, cigarette smoke, interleukin-1beta , and epidermal growth factor
Qin et al., J Immunol 2006 : IL-10 inhibits LPS induced IFN-beta gene expression and subsequent STAT-1alpha activation, but does not affect NF-kappaB activation
Hohmann et al., J Biol Chem 1992 (Leukemia, Promyelocytic, Acute) : NF-kappa B activation by phorbol 12-myristate 13-acetate ( PMA ) and interleukin-1 was inhibited by staurosporin
Manna et al., Clin Cancer Res 2007 (Inflammation...) : We showed by DNA binding assay that NF-kappaB activation induced by tumor necrosis factor (TNF), phorbol 12-myristate 13-acetate, lipopolysaccharide, ceramide, interleukin-1 , and H ( 2 ) O ( 2 ) was suppressed by morin ; the suppression was not cell type specific
Krasnow et al., Cytokine 1991 (Lymphoma, T-Cell) : Tumor necrosis factor-alpha, interleukin 1, and phorbol myristate acetate are independent activators of NF-kappa B which differentially activate T cells
Szabo et al., Pancreatology 2007 (Pancreatitis, Alcoholic) : The effects of acute or chronic alcohol exposure were evaluated in human monocytes on the production of TNFalpha or IL-10 production, pro-inflammatory gene and nuclear factor-kappaB (NF-kappaB) activation ... In contrast, acute alcohol treatment augmented NF-kappaB activation and TNFalpha production and inhibited IL-10 levels in the presence of complex stimulation with combined TLR2 and TLR4 ligands
Lafarge et al., BMC molecular biology 2007 : In response to IL1beta, or IL10 , the levels of phosphorylated NF-kappaB and STAT3 -- respectively -- increased significantly for all the studied cell types
Shembade et al., J Virol 2007 : Mouse fibroblasts lacking Ubc13 exhibit impaired Tax activation of NF-kappaB despite normal tumor necrosis factor- and interleukin-1 mediated NF-kappaB activation
Voboril et al., Neoplasma 2007 (Colorectal Neoplasms) : IL-4 or IL-10 ( 1, 10, 100 ng/ml ) neither inhibited growth and clonogenicity nor activated NF-kappaB , but they sensitized cells to irradiation in a dose dependent manner
Dey et al., Cell Death Differ 2008 : We show in this study that R-Roscovitine can downregulate nuclear factor-kappa B (NF-kappaB) activation in response to tumor necrosis factor (TNF)alpha and interleukin 1
Kim et al., Mol Pharmacol 2008 (Inflammation...) : BOT-64 attenuates NF-kappaB regulated expression of inflammatory genes such as inducible nitric-oxide synthase, cyclooxygenase-2, tumor necrosis factor-alpha, interleukin (IL)-1beta , and IL-6 in LPS activated or expression vector IKKbeta transfected macrophages
Xiao et al., J Biol Chem 2008 : Pellino 3b negatively regulates interleukin-1 induced TAK1 dependent NF kappaB activation
Samanta et al., Oncogene 2008 (Burkitt Lymphoma) : Blocking of nuclear factor (NF)-kappaB by dominant negative IkappaB-alpha plasmid did not block IL-10 expression, whereas knockdown of IRF-3 by siRNA resulted in downregulation of IL-10 in EBER ( + ) BL cells
Hickey et al., J Leukoc Biol 2008 : CyaA enhanced LPS induced phosphorylation of p38 MAPK and ERK in DC, and inhibitors of p38 MAPK, MEK, or NF-kappaB suppressed IL-10 production in response to LPS and CyaA
Lin et al., J Ethnopharmacol 2008 (Shock, Septic) : These results suggested that ASE protected mice against LPS/D-GalN induced endotoxic shock involving inhibition of NF-kappaB activation, which caused down-regulation of TNF-alpha and involved up-regulation of IL-10
Kim et al., J Microbiol Biotechnol 2008 (MAP Kinase Signaling System) : These results suggest that the synergistic effect of PGA1 on LPS induced IL-10 expression is NF-kappaB dependent and mediated by mitogen activated protein ( MAP ) kinases, p38, and SAPK/ JNK signaling pathways, and also associated with the PPARgamma pathway
Dasu et al., Diabetes 2008 : High glucose increased TLR expression, myeloid differentiation factor 88, interleukin-1 receptor associated kinase-1, and nuclear factor-kappaB (NF-kappaB) p65 dependent activation in THP-1 cells
Wijagkanalan et al., Mol Pharmacol 2008 (Pneumonia) : DPML significantly inhibited tumor necrosis factor alpha, interleukin-1beta , and cytokine induced neutrophil chemoattractant-1 levels, suppressed neutrophil infiltration and myeloperoxidase activity, and inhibited NFkappaB and p38 mitogen activated protein kinase activation in the lung
Leghmari et al., Cell Immunol 2008 : Using chemical inhibitors we show that ( i ) both ERK1/2 MAP kinase and NF-kappaB transcription factor play an important role in IL-10 and TNF-alpha production, in macrophages stimulated by Tat
Dagvadorj et al., Innate Immun 2008 : IL-10 inhibited the activation of nuclear factor (NF)-kappaB , p38 and stress activated protein kinase ( SAPK ) in LPS stimulated RAW 264.7 cells
Inagaki et al., J Biol Chem 2008 : Tumor necrosis factor- and interleukin-1 induced activation of TAK1 was entirely normal in Tab1-deficient MEFs and could activate both mitogen activated protein kinases and NF-kappaB
Dhingra et al., Cardiovasc Res 2009 : IL-10 attenuates TNF-alpha induced NF kappaB pathway activation and cardiomyocyte apoptosis ... IL-10 prevents TNF-alpha induced NF kappaB activation and pro-apoptotic changes in cardiomyocytes by inhibiting IKK phosphorylation through the activation of ERK 1/2 MAPK
Jie Zhao et al., Innate Immun 2009 (Aspergillosis...) : In addition, the A. fumigatus antigens induced production of IL-1beta and IL-10 in supernatants of corneal epithelial cells was also attenuated by NF-kappaB inhibitor
Gao et al., Cell Mol Life Sci 2009 : Transforming growth factor-beta activated kinase 1 ( TAK1 ) is a serine/threonine protein kinase that is critically involved in the activation of NF-kappaB by tumor necrosis factor ( TNFalpha ), interleukin-1beta (IL-1beta) and TLR ligands
Dagvadorj et al., Innate Immun 2009 : Further, IL-10 inhibited LPS induced NF-kappaB activation
Cheng et al., Infect Immun 2009 (Inflammation) : These results suggest that GSK-3beta regulates heat inactivated S. aureus induced TNF-alpha and NO production in microglia mainly by activating NF-kappaB and probably by inhibiting IL-10
de Mejia et al., Peptides 2009 (Inflammation) : The 5 kDa peptide inhibited most potently pro-inflammatory markers including interleukin-6 production ( IC ( 50 ) =2 microM ), interleukin-1beta production ( IC ( 50 ) =13 microM ), nuclear factor-kappa B (NF-kappaB) transactivation ( IC ( 50 ) =21 microM ), cyclooxygenase-2 expression ( IC ( 50 ) =25 microM ), nitric oxide production ( IC ( 50 ) =28 microM ), inducible nitric oxide synthase expression ( IC ( 50 ) =37 microM ), prostaglandin E ( 2 ) production ( IC ( 50 ) =41 microM ), p65 nuclear translocation ( IC ( 50 ) =48 microM ) and p50 nuclear translocation ( IC ( 50 ) =77 microM )
Zhou et al., Exp Neurol 2009 (Disease Models, Animal...) : We have previously reported that the anti-inflammatory cytokine IL-10 induces a number of signaling cascades through the IL-10 receptor in spinal cord neurons in vitro to activate NF-kappaB transcription Bcl-2 and Bcl-x ( L ) and that, after exposure to glutamate IL-10, blocks cytochrome c release and caspase cleavage
Samanta et al., Cancer Sci 2010 (Burkitt Lymphoma) : In BL cells, EBERs activate RIG-I signaling and induce the expression of type-I IFNs and interferon stimulated genes ( ISGs ) through the activation of RIG-I substrates, nuclear factor-kappa B (NF-kappaB), and IFN regulatory factor 3 (IRF-3), and anti-inflamatory cytokine IL-10 through IRF-3 but not NF-kappaB signaling
Sheller et al., Exp Lung Res 2009 (Asthma...) : Accompanying the exaggerated inflammation was an increase in the cytokines granulocyte colony stimulating factor ( G-CSF ), interleukin (IL)-15, and KC. Interestingly, the counter regulatory interleukin , IL-10, was suppressed by NF-kappa B activation
Wang et al., FASEB J 2010 (Hypercapnia) : In contrast, hypercapnia did not down-regulate IL-10 or interferon-beta, which do not require NF-kappaB
Munitz et al., Gastroenterology 2010 (Colitis...) : In vitro analysis showed increased production of proinflammatory cytokines ( interleukin-6, interleukin-1beta , and tumor necrosis factor alpha ) and activation of MAPK and NF-kappaB in Pirb-/- macrophages following bacterial activation
Iwakiri et al., Adv Cancer Res 2010 (Burkitt Lymphoma...) : Furthermore, EBERs induce IL-10 through IRF3 but not NF-kappaB activation in BL cells, suggesting that modulation of innate immune signaling by EBERs contribute to EBV mediated oncogenesis
Schreck et al., EMBO J 1991 : NAC and other thiol compounds also blocked the activation of NF-kappa B by cycloheximide, double stranded RNA, calcium ionophore, TNF-alpha, active phorbol ester, interleukin-1 , lipopolysaccharide and lectin
Ropelle et al., PLoS Biol 2010 (Hyperphagia...) : This molecular mechanism, mediated by physical activity, involves the anti-inflammatory protein IL-10 , a core inhibitor of IKKbeta/NF-kappaB signaling and ER stress
Sarkar et al., Mol Cell Biol 2011 : RNA binding protein AUF1 regulates lipopolysaccharide induced IL10 expression by activating IkappaB kinase complex in monocytes
Powolny-Budnicka et al., Immunity 2011 (Bacterial Infections) : RelA and RelB transcription factors in distinct thymocyte populations control lymphotoxin dependent interleukin-17 production in ?d T cells
Jan et al., Microbiol Immunol 2012 : Inhibition of nuclear factor (NF)-kappa B ( ?B ) by helenalin and p38 mitogen activated protein kinase ( MAPK ) by SB203580 prevented production of IL-12 p40, IL-12 p70, and IL-10
Mahon et al., J Biol Chem 1995 (Lymphoma, T-Cell...) : The tyrosine kinase inhibitor herbimycin A was found to block NF-kappa B stimulation in response to interleukin-1 and phorbol 12-myristate 13-acetate in EL4.NOB-1 thymoma cells and phorbol 12-myristate 13-acetate in Jurkat T lymphoma cells
Lewis et al., Mol Cell Biol 1994 : Mutational analysis of the -127/-118 NF-kappa B site indicates that both NF-kappa B and HMG-I(Y) binding at this site are essential for interleukin-1 induction of the promoter
Wang et al., J Biol Chem 1995 : Interleukin (IL)-10 inhibits nuclear factor kappa B (NF kappa B) activation in human monocytes ... Using electrophoretic mobility shift assays ( EMSA ), we now show that, in monocytes stimulated with LPS or TNF alpha, IL-10 inhibits nuclear stimulation of nuclear factor kappa B (NF kappa B) , a transcription factor involved in the expression of inflammatory cytokine genes
Scheinman et al., Mol Cell Biol 1995 : In HeLa cells, DEX activation of endogenous GR is sufficient to block tumor necrosis factor alpha or interleukin 1 activation of NF-kappa B at the levels of both DNA binding and transcriptional activation
Hurme et al., Immunol Lett 1994 : Effect of interleukin-10 on NF-kB and AP-1 activities in interleukin-2 dependent CD8 T lymphoblasts
Ng et al., J Biol Chem 1994 : Although tumor necrosis factor (TNF) and interleukin-1 ( IL ) induce the expression of the IL-8, TNF stimulated gene 6, and plasminogen activation inhibitor-2 genes and the activation of NF-kappa B with nearly identical kinetics, the two cytokines differ significantly in the induction of the IL-6 gene in all primary fibroblasts tested
Finnegan et al., J Immunol 1996 (Lymphoma, Large B-Cell, Diffuse) : In combination with TNF-alpha, IL-10 stimulated activating protein-1 (AP-1) and nuclear factor (NF)-kappa B binding activities and cooperated to increase HIV-1 steady-state mRNA levels and enhance long terminal repeat directed transcription through activation of the NF-kappa B binding sites, suggesting the IL-10 effect occurs at least in part at the transcriptional level
Romano et al., J Immunol 1996 : IL-10 markedly reduces nuclear factor (NF)-kappa B/Rel nuclear activity induced in PBMC by stimulation with the anti-CD3 mAb OKT3 ... Our results demonstrate that IL-10 can inhibit the induction of NF-kappa B/Rel nuclear activity in CD3 stimulated T lymphocytes
Mori et al., Blood 1996 (Leukemia-Lymphoma, Adult T-Cell) : These data suggest a general role for NF-kappa B activation in the induction of IL-10 gene transcription
Dokter et al., Leukemia 1996 : Neither IL-10 nor IL-4 inhibited LPS induced NF-kappa B binding activity
Takeshita et al., J Immunol 1996 : Electrophoretic mobility shift assays showed that IL-4, but not IL-10 , inhibited nuclear NF-kappaB activity, and that IL-4 and IL-10 did not affect NF-IL-6 activity
De Valck et al., Biochem Biophys Res Commun 1997 : However, A20 mutants that no longer associated with 14-3-3 proteins could still fully inhibit NF-kappaB activation induced by tumor necrosis factor, interleukin-1beta or phorbol 12-myristate 13-acetate, thus excluding a crucial role for 14-3-3 interaction in this A20 function
Bowie et al., J Biol Chem 1997 : Here we have investigated the effect of a range of putative antioxidants on NF-kappaB activation by interleukin-1 and tumor necrosis factor as well as the ability of H2O2 to activate NF-kappaB in primary human umbilical vein endothelial cells and the transformed human endothelial cell line ECV304
Lentsch et al., J Clin Invest 1997 : In this study, we sought to determine whether the protective effects of IL-10 and IL-13 in IgG immune complex induced lung injury were mediated by inhibition of NF-kappa B activation
Chaturvedi et al., J Biol Chem 1997 : As sanguinarine also inhibited NF-kappaB activation induced by interleukin-1 , phorbol ester, and okadaic acid but not that activated by hydrogen peroxide or ceramide, the pathway leading to NF-kappaB activation is likely different for different inducers
Gri et al., J Biol Chem 1998 (Cell Transformation, Viral) : Synergistic regulation of the human interleukin-12 p40 promoter by NFkappaB and Ets transcription factors in Epstein-Barr virus transformed B cells and macrophages
Giri et al., J Biol Chem 1998 (Lymphoma, T-Cell...) : HuT-78 cells were also resistant to NF-kappaB activation induced by phorbol ester, H2O2, ceramide, endotoxin, and interleukin-1
Clarke et al., Eur J Immunol 1998 : In this study we observed that IL-10 inhibited nuclear NF kappa B DNA binding activity without affecting I kappa B degradation or translocation of NF kappa B subunits to the nucleus ... Therefore we conclude that although IL-10 or IL-4 can suppress NF kappa B activity, this appears to have little effect on the expression of the TNF-alpha gene and is unlikely to be the basis of the anti-inflammatory effects of these cytokines
Heitmeier et al., J Biol Chem 1998 : Double stranded RNA induced inducible nitric-oxide synthase expression and interleukin-1 release by murine macrophages requires NF-kappaB activation
Schwager et al., Vet Immunol Immunopathol 1998 (Ascorbic Acid Deficiency...) : The results suggest that ascorbate levels exert an early effect on immune homeostasis via reactive oxygen intermediates ( ROI ) -dependent expression of interleukin genes, since the transcription factor NF-kappa B is sensitive to ROI and regulates the expression of interleukin genes
Shames et al., Shock 1998 (Endotoxemia) : Evidence suggests that IL-10 may inhibit activation of the transcription factor nuclear factor-kappaB (NF-kappaB) through an unknown mechanism ... The purpose of this study was to determine the effect of IL-10 on lipopolysaccharide (LPS) induced human monocyte TNF-alpha production, NF-kappaB activation, and IkappaB-alpha degradation
Béraud et al., Proc Natl Acad Sci U S A 1999 : The compound had virtually no effect on tumor necrosis factor- and interleukin-1 induced NF-kappaB activities