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BBS2 — PRL

Text-mined interactions from Literome

Törnquist et al., Endocrinology 1991 : However, the BBS induced secretion of PRL was enhanced in cells pretreated with 1,25- ( OH ) 2D3 for 24 h compared with that in vehicle treated control cells ... The enhanced transient increase in [Ca2+ ] i may be the factor inducing the enhanced BBS induced secretion of PRL
Bjøro et al., Regul Pept 1987 : Bombesin (BBS) stimulated prolactin (PRL) secretion from monolayer cultures of rat pituitary tumour cells ( GH4C1 ) in a dose dependent manner with half maximal and maximal effect at 2 nM and 100 nM, respectively ... These results suggest that BBS stimulates PRL secretion from the GH4C1 cells via a mechanism involving the immediate formation of IP3 thus resembling the action of TRH
Westendorf et al., Endocrinology 1982 : The BBS analogs ranatensin, litorin, and [ Tyr4 ] BBS , each at a concentration of 100 nM, caused the same stimulation of PRL release as maximal concentrations of BBS itself ... Pretreatment of GH4C1 cells with 1 nM estradiol and/or 100 nM insulin resulted in more powerful stimulation of PRL release by both TRH and BBS ... These results suggest that BBS may stimulate PRL and GH secretion in vivo by direct action on the pituitary gland