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FAS — PPP2R1A
Text-mined interactions from Literome
Chalfant et al., J Biol Chem 2001
:
The serine/threonine protein phosphatase inhibitor, calyculin A, but not the
PP2A-specific inhibitor, okadaic acid,
inhibited both
FAS- and ceramide induced dephosphorylation of SR proteins
Park et al., Cancer Res 2010
(Gastrointestinal Neoplasms) :
ROS generation,
CD95 activation , and cell killing was also blocked by quenching of induced Ca ( 2+ ) levels or by inhibition of
PP2A
Kwan et al., Eur J Nutr 2013
:
Inhibition of
PP2A by okadaic acid, knockdown of DNA-PK by siRNA or inhibition of DNA-PK by specific DNA-PK inhibitors curtailed the FFA induced upregulations of the SREBP1 mRNA expression and the nuclear active SREBP1 protein expression, and
reduced FFA induced upregulation of
FAS promoter transcriptional activity and lipid accumulation