◀ Back to PI3

PI3 — TIMP1

Text-mined interactions from Literome

Boulday et al., Ann N Y Acad Sci 2004 : We present evidence that TIMP-1 induces activation of PI3-kinase but not NFkappaB pathway in ECs ... In conclusion, our findings suggest that TIMP-1 , generated upon inflammation, acts as an antiapoptotic molecule that can prevent EC apoptosis through activation of the PI3-kinase and phosphorylation of the Akt kinase
Kadri et al., Mol Cell Biol 2005 : We report here that erythropoietin regulates the transcription of the TIMP-1 gene upon binding to its receptor in erythroid cells by triggering the activation of phosphatidylinositol 3-kinase (PI3K)/Akt
Guo et al., Calcif Tissue Int 2006 : TIMP-1 activated phosphatidylinositol 3-kinase ( PI3-kinase ) and c-Jun N-terminal kinase (JNK), and the PI3-kinase inhibitor LY294002 or the JNK inhibitor SP600125 abolished its antiapoptotic activity
Fu et al., Biomed Pharmacother 2011 (Breast Neoplasms) : TIMP-1 can potently activate phosphatidylinositol 3-kinase (PI3K)/Akt and nuclear factor-kappaB ( NF-?B ) signaling