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PI3 — SETD2

Text-mined interactions from Literome

Li et al., Cancer Res 2004 : Inhibition of PI-3K , Akt, and p70 ( S6k ) by overexpression of a dominant negative mutant of PI-3K ( Deltap85 ) impaired nickel induced HIF-1 transactivation
Alam et al., J Biol Chem 2004 : FSH stimulated HIF-1 activity is inhibited by the PI 3-kinase inhibitor LY294002, the Rheb inhibitor FTI-277 ( farnesyltransferase inhibitor-277 ), and the mTOR inhibitor rapamycin
Shi et al., Zhonghua Yi Xue Za Zhi 2004 (Breast Neoplasms) : [ Activation of HIF-1 by bFGF in breast cancer : role of PI-3K and MEK1/ERK pathways ]
Trisciuoglio et al., Mol Biol Cell 2005 (MAP Kinase Signaling System...) : Pharmacological inhibition of mitogen activated protein kinase ( MAPK ) and phosphatidylinositol 3-kinase (PI3K) signaling pathways reduced the induction of VEGF and HIF-1 in response to bcl-2 overexpression in hypoxia
Alam et al., Endocrinology 2009 : These results indicate that FSH stimulated HIF-1 activation leading to up-regulation of targets such as vascular endothelial growth factor requires not only PI3-kinase/AKT mediated activation of mammalian target of rapamycin as well as phosphorylation of FOXO1 and possibly MDM2 but also a protein ( kinase ) activity that is inhibited by the classic ERK kinase inhibitor PD98059 but not ERK1/2 or 5
He et al., Rheumatol Int 2011 (Arthritis, Rheumatoid) : TNFa- or hypoxia induced secretion of VEGF and IL-8 and expression of HIF-1a were hampered by treatment with the PI3 kinase inhibitor LY294002, suggesting that inhibition of PI3 kinase/Akt activation might inhibit VEGF and IL-8 secretion and HIF-1a expression induced by TNFa or hypoxia
Choi et al., J Biol Chem 2010 : These translational signal events and HIF-1a protein level were suppressed by inhibitors of phosphatidylinositol 3-kinase (PI3K) , MEK, and mTOR, suggesting that the PI3K/Akt/mTOR and MEK/ERK pathways are involved in a translational increase in HIF-1a
Chern et al., Planta Med 2011 (Cerebral Infarction...) : In BV-2 cells, OGD induced ROS and nitric oxide production by upregulating NOX2 and iNOS via the phosphatidylinositol-3-kinase (PI3K)/AKT dependent NF- ?B and HIF-1 a pathways, and these changes were suppressed by andrographolide and LY294002
Burrows et al., J Clin Endocrinol Metab 2011 (Carcinoma...) : Phosphoinositide 3-kinase (PI3K) regulates the transcription factor hypoxia-inducible factor-1 (HIF-1) in thyroid carcinoma cells
Li et al., Mol Cell Biochem 2013 (Arthritis, Experimental...) : HIF-1a could be blocked by phosphatidylinositol 3-kinase (PI3K) inhibitor, LY294002, indicating that HIF-1a activation was regulated by the PI3K/Akt pathway