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PDGFRB — PI3

Text-mined interactions from Literome

Veevers-Lowe et al., J Cell Sci 2011 : PDGFR-ß induced phosphoinositide 3-kinase (PI3K) and Akt activity, actin reorganisation and cell migration were all regulated by fibronectin and a5ß1-integrin
Isakoff et al., Proc Natl Acad Sci U S A 1995 : To investigate the role of PI3-kinase and IRS-1 in insulin stimulated glucose uptake we examined whether stimulation of insulin-sensitive cells with platelet derived growth factor ( PDGF ) or with interleukin 4 (IL-4) stimulates glucose uptake ; the activated PDGF receptor (PDGFR) directly binds and activates PI3-kinase , whereas the IL-4 receptor (IL-4R) activates PI3-kinase via IRS-1 or the IRS-1 related molecule 4PS ... We found that stimulation of 3T3-L1 adipocytes with PDGF resulted in tyrosine phosphorylation of the PDGFR and activation of PI3-kinase in these cells
Moriya et al., Proc Natl Acad Sci U S A 1996 : A PDGFR mutant ( Y1021 ) that binds and activates phospholipase C gamma (PLC gamma), but not PI 3-kinase , also caused the PDGF dependent translocation of PKC epsilon
Kubota et al., Cell Growth Differ 1998 : Accordingly, activation of PDGF-R- , CSF-1R-, and EK-R expressing cells led to an increase in PI3-kinase activity