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EPX — PI3

Text-mined interactions from Literome

Boudot et al., Biochem Biophys Res Commun 2003 : Our results suggest that the Src kinase Lyn is involved in PLC-gamma 2 phosphorylation and PI 3-kinase activation induced by Epo
Bouscary et al., Blood 2003 (MAP Kinase Signaling System) : Using different in vitro systems, we demonstrate that 3 alternative pathways independently lead to Epo induced activation of PI 3-kinase and phosphorylation of its downstream effectors, Akt, FKHRL1, and P70S6 kinase : through direct association of PI 3-kinase with the last tyrosine residue ( Tyr479 ) of the Epo receptor (EpoR), through recruitment and phosphorylation of Gab proteins via either Tyr343 or Tyr401 of the EpoR, or through phosphorylation of IRS2 adaptor protein