Gene interactions and pathways from curated databases and text-mining

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NOS3 — PRKCB

Text-mined interactions from Literome

Chu et al., American journal of physiology. Renal physiology 2004 (Hyperglycemia) : Inhibition of PKC-beta with 100 nM ruboxistaurin prevented eNOS suppression in high-glucose media
Naruse et al., Diabetes 2006 (Atherosclerosis...) : Thus, activation of PKCbeta in endothelial cells and vascular tissue inhibits Akt activation by insulin and VEGF, inhibits Akt dependent eNOS regulation by insulin, and causes endothelial dysfunction in obesity associated insulin resistance
Payne et al., Am J Physiol Heart Circ Physiol 2009 : Periadventitial adipose tissue impairs coronary endothelial function via PKC-beta dependent phosphorylation of nitric oxide synthase ... This site-specific phosphorylation of eNOS was prevented by the inhibition of PKC-beta