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Chen et al., Am J Physiol Heart Circ Physiol 2005
(Heart Failure) :
Decreased DDAH activity and DDAH-2 protein expression may cause accumulation of endogenous inhibitors of endothelial NOS , thereby contributing to endothelial dysfunction in the failing heart
Pope et al., Pharmacol Res 2009
(Cardiovascular Diseases) :
However, recent studies suggest that DDAH may regulate eNOS activity and endothelial function through both ADMA dependent and -independent mechanisms