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Vuong et al., Am J Physiol Lung Cell Mol Physiol 2002
(Adenocarcinoma, Bronchiolo-Alveolar...) :
Interestingly, unlike in S6 cells, a catalytically inactive c-Jun NH ( 2 ) -terminal kinase ( JNK ) 1 mutant significantly reduced the PMA-inducible SPRR1B promoter activity in H441 cells
Reddy et al., Am J Respir Cell Mol Biol 2002
:
We have recently shown that phorbol 13-myristate 12-acetate ( PMA ) -stimulated SPRR1B transcription in Clara-like H441 cells is mainly mediated by activator protein-1 (AP-1) and c-Jun N-terminal kinase-1 ( JNK1 ) ... Thus, in addition to JNK1, the activation of MEK5-ERK5 MAPK pathway probably plays a pivotal role in transcriptional regulation of AP-1 mediated SPRR1B expression in the distal bronchiolar region