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JUN — PLAUR
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
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Complex of PLAU-PLAUR
(increases, PLAU/PLAUR Activity)
Evidence: In addition to the influence on the protein kinase system, uPA can regulate gene expression. The binding of uPA to uPAR has been shown to stimulate downstream up-regulation of various transcription factors: AP1 in the HT-1080 cell line [54] and c-Jun, c-Myc, and c-fos factors in SaOS2 cells [55]. Recently, the possibility of signal transduction into the cell by the receptor systems associated with urokinase endocytosis was shown [56].
Text-mined interactions from Literome
Okan et al., Oncogene 2001
:
The small-GTPase RalA activates transcription of the urokinase plasminogen activator receptor (
uPAR ) gene via an
AP1 dependent mechanism ... Here we show that
uPAR transcription is stimulated by V12 H-Ras, the effector loop mutant V12 H-Ras G37 and constitutively-active RalA 72L. RalA dependent transcription
required the presence of the ATF2-like
AP1-site at -70 bp and the c-Jun binding motif at -184 bp in the uPAR promoter ... These data provide evidence for the existence of a novel signalling pathway that links RalA to the activation of
uPAR transcription via a c-Src intermediate and
activation of
AP1
Kim et al., Int J Oncol 2005
(Neoplasm Invasiveness...) :
Transient transfection studies using AP-1 decoy confirmed that the activation of
AP-1 is
involved in PMS induced
uPAR upregulation
Leupold et al., Mol Cancer Res 2007
(Colorectal Neoplasms...) :
The present study was conducted ( a ) to investigate if, in particular, AP-1 related transcriptional mediators are required for Src induced u-PAR-gene expression, ( b ) to show in vivo relevance of
AP-1 mediated Src induced
u-PAR gene expression for invasion/intravasation and for resected tissues from colorectal cancer patients
Baek et al., Oncol Rep 2008
(Carcinoma...) :
Suppression of the EGF induced uPAR promoter activity by the AP-1 decoy oligonuclotide, as well as expression vectors encoding mutated-type NF-kappaB inducting kinase and I-kappaB, confirmed that the activation of
AP-1 and NF-kappaB are
essential for the EGF induced
uPAR upregulation
Khoi et al., Toxicol Appl Pharmacol 2012
(MAP Kinase Signaling System) :
Studies with expression vectors encoding mutated NF-?B signaling molecules and AP-1 decoy confirmed that NF-?B and
AP-1 were
essential for the nicotine stimulated
uPAR expression
Dear et al., FEBS Lett 1997
(Fibrosarcoma...) :
Since transcription factors bound to AP-1 recognition sequences within the PAI-2 gene promoter play a role in basal and phorbol ester mediated induction of PAI-2 gene expression, we hypothesised that
u-PA/u-PAR mediated modulation of
AP-1 activity would in turn influence constitutive and inducible PAI-2 gene expression