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CDK5 — JUN

Text-mined interactions from Literome

Honjyo et al., Neuroreport 1999 : Cdk5 requires either p39 or p35 to assume its active form in the mammalian CNS
Liu et al., Neurobiol Aging 2009 : Inhibition of proteasome resulted in activation of cAMP dependent protein kinase, glycogen synthase kinases-3beta and cyclin dependent kinase-5 , and inhibition of protein phosphatase-2A and c-Jun N-terminal kinase (JNK)
Sun et al., Mol Biol Cell 2009 (Alzheimer Disease) : In the second phase, Cdk5 activates c-Jun via ROS mediated activation of JNK
Chang et al., J Neurochem 2010 (Alzheimer Disease) : Importantly, Cdk5 mediated p38 activation increases c-Jun expression, thereby revealing a mechanistic link between deregulated Cdk5 and c-Jun level in AD brains
Jalili et al., J Natl Cancer Inst 2012 (MAP Kinase Signaling System...) : Using a dominant negative approach, in vitro cell proliferation assays, western blots, and flow cytometry showed that MAPK signaling via BRAF ( V600E ) promotes melanoma cell proliferation at G1 through AP-1 mediated negative regulation of the INK4 family member, cyclin dependent kinase inhibitor 2C ( CDKN2C ), and the CIP/KIP family member, cyclin dependent kinase inhibitor 1A ( CDKN1A )