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AR — IL8

Text-mined interactions from Literome

Lee et al., Oncogene 2004 (Prostatic Neoplasms) : We demonstrate that IL-8 activates the androgen receptor and confers androgen independent growth, while serving as a potent chemotactic factor ... Our evidence that IL-8 induced androgen independent growth is, at least in part, due to androgen receptor activation includes ( 1 ) an inhibitor of androgen receptor activity diminishes cell growth ; ( 2 ) androgen receptor transactivation potential is augmented by IL-8 and ( 3 ) androgen receptor is recruited to the promoter of prostate specific antigen (PSA) upon IL-8 treatment, based on chromatin immunoprecipitation experiments ... To our knowledge, this is the first report about the tyrosine kinase signals and androgen receptor activation induced by IL-8 in prostate cancer cells
Wang et al., Cancer Biol Ther 2007 (Carcinoma...) : The effect of IL-6 and IL-8 on cell growth and androgen receptor (AR) expression was also analyzed