Gene interactions and pathways from curated databases and text-mining

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IL3 — IL3RA

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Brown et al., Blood 1999 : In vitro, we show that an early IL-7R ( + ) lymphoid progenitor population expresses IL-3R and proliferates in response to IL-3 and that IL-3 activates Stat5 comparably to IL-7
Gregory et al., J Immunol 2003 : In contrast to these findings, eosinophil expression of IL-3R alpha was increased by IL-3 , IL-5, and GM-CSF, whereas GM-CSF receptor alpha was down-regulated by GM-CSF, but was not affected by IL-3 or IL-5
Yoshimura-Uchiyama et al., Biochem Biophys Res Commun 2003 : IL-3 at 30pM significantly increased IL-3Ralpha expression and IL-3Ralpha expression was also upregulated by both IL-5 and GM-CSF
Algate et al., Blood 1994 : We conclude that IL-3 tightly controls IL-3R expression in the IL-3 dependent FL5.12 cells, whereas steady-state mRNA levels were not altered in the two v-abl transformed derivative cell lines examined in this study
Dan et al., J Immunol 1996 : A subset of type 2, but not type 1, CD4 T cell clones expresses IL-3R and can be stimulated by IL-3 ... Expression of IL-3R on these type 2 T cell clones is induced by TCR stimulation, and subsequent stimulation by IL-3 augmented the proliferation of and IL-4 production by these cells
Stomski et al., Mol Cell Biol 1996 : However, in the presence of IL-3, each MAb immunoprecipitated both IL-3R alpha and beta c. IL-3 induced receptor dimers were disulfide and nondisulfide linked and were dependent on IL-3 interacting with both IL-3R alpha and beta c