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IL11 — IL1A
Text-mined interactions from Literome
Taki et al., Atherosclerosis 1999
(Arteriosclerosis) :
IL-1 alpha, transforming growth factor-beta ( TGF beta ) and, to a lesser extent, tumor necrosis factor-alpha (TNF alpha) stimulated the IL-11 production by VSMC, and the stimulatory
effects of
IL-1 alpha and TGF beta on
IL-11 production were dose dependent ...
IL-1 alpha and TNF alpha synergistically augmented TGF beta
stimulated IL-11 production by VSMC ... Furthermore,
IL-1 alpha , TGF beta, and TNF alpha
induced IL-11 gene expression in VSMC
De Caterina et al., Am J Clin Nutr 2000
(Arteriosclerosis) :
Consumption of the n-3 fatty acid docosahexaenoic acid ( DHA ; 22 : 6n-3 ) reduced endothelial expression of vascular cell adhesion molecule 1 ( VCAM-1 ), E-selectin, intercellular adhesion molecule 1 ( ICAM-1 ),
interleukin 6 (IL-6), and IL-8 in
response to
IL-1 , IL-4, tumor necrosis factor, or bacterial endotoxin, with a half-maximal inhibitory concentration ( IC ( 50 ) ) of 1-25 micromol, ie, in the range of nutritionally achievable plasma concentrations
Zeyse et al., Biol Reprod 2000
:
Induction of
interleukin-1alpha production in murine Sertoli cells by
interleukin-1
Cork et al., J Reprod Immunol 2001
:
The
effects of TNFalpha,
IL-1alpha and TGFbeta on
IL-11 production by epithelial and stromal cells was also investigated ...
IL-1alpha , TNFalpha and TGFbeta ( 0.1-10 ng/ml ) all
caused a concentration dependent increase in
IL-11 production by both epithelial and stromal cells, but stimulated : basal values were greater for stromal than epithelial cells for all three cytokines
He et al., Zhonghua Kou Qiang Yi Xue Za Zhi 2004
:
IL-1alpha significantly
increased the levels of
IL-11 in HGFs. TNF-alpha also significantly augmented IL-11 production in HGFs, and synergistically stimulated HGFs to produce IL-11 when combined with IL-1alpha
Van Damme et al., J Invest Dermatol 1990
:
This study focuses on interferon-beta (IFN-beta),
interleukin-6 (IL-6), and interleukin-8 (IL-8) production by fibroblasts and epithelial cells in
response to
interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha)
Nagineni et al., Biochem Biophys Res Commun 2010
:
TNF-alpha+IL-1 induced
IL-11 secretion and this production was inhibited by NFkappaB pathway inhibitors ... RT-PCR analysis confirmed the
effects of
IL-1 , TNF-alpha, IFN-gamma and TGF-beta on
IL-11 secretion at mRNA levels
Elias et al., Chest 1990
(Pneumonia...) :
To understand the processes regulating inflammation and fibrosis in the human lung, we characterized the
effects of recombinant
interleukin-1 , tumor necrosis factor, and gamma interferon on fibroblast proliferation, collagen production,
interleukin-1-alpha production, interleukin-1-beta production, and interleukin-6 production
Seckinger et al., J Immunol 1987
(Fever) :
A urine inhibitor of
interleukin 1 activity
affects both
interleukin 1 alpha and 1 beta but not tumor necrosis factor alpha
Grosset et al., Blood 1995
:
In vitro biosynthesis of leukemia inhibitory factor/human
interleukin for DA cells by human endothelial cells : differential
regulation by
interleukin-1 alpha and glucocorticoids
Yang et al., Blood 1995
:
We observed that both
interleukin-1 (IL-1) and 12-O-tetradecanoylphorbol-13-acetate ( TPA ) can
stimulate the expression of
IL-11 and granulocyte-macrophage colony stimulating factor ( GM-CSF ) genes in a primate bone marrow stromal fibroblast cell line, PU-34
Elias et al., J Biol Chem 1994
:
Unstimulated cells produced low levels of IL-11, while
IL-1 , transforming growth factor ( TGF-beta 1 ), and respiratory syncytial virus ( RSV )
stimulated IL-11 protein production and mRNA accumulation in a time- and dose dependent fashion ... Thus,
IL-1 , TGF-beta, and RSV
stimulate epithelial-like cell
IL-11 production, and RA regulates these inductive processes in a stimulus-specific fashion
Boxman et al., J Invest Dermatol 1993
:
Low
interleukin-1 activity was most probably not
due to inhibition of
interleukin-1 alpha production in squamous carcinoma cells-4/3T3 co-cultures because interleukin-1 alpha messenger RNA expression in squamous carcinoma cells-4 cells remained unchanged in the presence of 3T3 cells
Thalmeier et al., Exp Hematol 1996
:
IL-1 alpha induced GM-CSF, IL-1 beta, IL-6,
IL-11 , and LIF mRNA levels were reduced by the addition of dexamethasone, whereas dexamethasone had no influence on the amounts of IL-1 alpha induced G-CSF mRNA
Haynesworth et al., J Cell Physiol 1996
:
In contrast,
IL-1 alpha
increased the expression of G-CSF, M-CSF, LIF, IL-6 and
IL-11 and induced the expression of GM-CSF
Aman et al., Exp Hematol 1996
:
Synthesis of
IL-11 is
induced by
IL-1 and transforming growth factor-beta ( TGF-beta ) in stromal cells and fibroblasts, but the cytokines that inhibit its production remain to be defined ... In the present study, we demonstrate that interferon-alpha (INF-alpha) downregulates
IL-1 induced
IL-11 in human bone marrow stromal cultures ... In eight independent experiments,
IL-1 stimulated production of
IL-11 was significantly inhibited by INF-alpha ( p = 0.0117 ) as measured in stromal cell supernatants by specific enzyme linked immunosorbent assay ( ELISA )
Elias et al., Am J Physiol 1997
:
We demonstrated that HASM cells are potent producers of IL-11 when stimulated with IL-1 or transforming growth factor-beta 1 ( TGF-beta 1 ) and that
IL-11 levels are synergistically
increased by
IL-1 and TGF-beta 1 in combination ... These studies also demonstrated that
IL-1 and TGF-beta 1-stimulated HASM cells produce IL-6 and leukemia inhibitory factor but not oncostatin M and that respiratory syncytial virus and parainfluenza virus type 3
stimulate HASM cell
IL-11 production
Jiang et al., Blood 1998
(Acute Disease...) :
The expression of
IL-1alpha and IL-11 was induced in MS-10 by the direct contact with HB-1 cells, and the expression of IL-1 receptor type I (IL-1RI) and
interleukin-11 receptor (IL-11R) was
induced in HB-1 cells by the attachment of the cells to MS-10
Mino et al., Arthritis Rheum 1998
(Arthritis, Rheumatoid) :
Interleukin-1alpha and tumor necrosis factor alpha synergistically
stimulate prostaglandin E2-dependent production of
interleukin-11 in rheumatoid synovial fibroblasts ... Here, we characterized the combined
effect of
IL-1alpha and tumor necrosis factor alpha (TNFalpha), major cytokines in the rheumatoid synovium, on the production of
IL-11 by cultured rheumatoid synovial fibroblasts ( RSFs ) ... The synergistic
induction of
IL-11 by
IL-1alpha and TNFalpha was completely inhibited by a potent inhibitor of all isoforms of PKC, GF109203X ... These findings suggest that
IL-1alpha and TNFalpha synergistically stimulate the production of IL-11 via their effects on PGE2 production in the rheumatoid joint, and that atypical PKC may be another
target for down-regulation of
IL-11 , the bone resorption associated cytokine
Kim et al., J Endocrinol 1999
:
To determine if interleukin-6 (IL-6) or interleukin-11 (IL-11) could be the mediator ( s ) of thyroid hormone induced bone loss, we studied the effects of 3,5,3'-tri-iodothyronine ( T3 ) on basal and
interleukin-1 (IL-1) stimulated
IL-6/IL-11 production in primary cultured human bone marrow stromal cells