◀ Back to HRAS

HRAS — LGALS1

Pathways - manually collected, often from reviews:

• NCI Pathway Database Regulation of Ras family activation: HRAS/GTP/Galectin-1 complex (HRAS-LGALS1) → Galectin-1 (LGALS1) (modification, collaborate) Paz et al., Oncogene 2001*, Rotblat et al., Cancer Res 2004*, Belanis et al., Mol Biol Cell 2008*
  Evidence: physical interaction
• NCI Pathway Database Regulation of Ras family activation: HRAS/GTP/Galectin-1 complex (HRAS-LGALS1) → HRAS/GTP complex (HRAS) (modification, collaborate) Paz et al., Oncogene 2001*, Rotblat et al., Cancer Res 2004*, Belanis et al., Mol Biol Cell 2008*
  Evidence: physical interaction
• NCI Pathway Database Regulation of Ras family activation: Galectin-1 (LGALS1) → HRAS/GTP complex (HRAS) (modification, collaborate) Paz et al., Oncogene 2001*, Rotblat et al., Cancer Res 2004*, Belanis et al., Mol Biol Cell 2008*
  Evidence: physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: LGALS1 — HRAS (physical association, affinity chromatography technology) Paz et al., Oncogene 2001*
• IRef Hprd Interaction: LGALS1 — HRAS (in vivo) Paz et al., Oncogene 2001*
• IRef Hprd Interaction: LGALS1 — HRAS (in vitro) Paz et al., Oncogene 2001*
• IRef Ophid Interaction: LGALS1 — HRAS (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Prior et al., J Cell Biol 2003 : Galectin-1 stabilizes the association of activated H-ras with these nonraft microdomains, whereas K-ras clustering is supported by farnesylation, but not geranylgeranylation
Rotblat et al., Cancer Res 2004 (MAP Kinase Signaling System) : Galectin-1 ( L11A ) predicted from a computed galectin-1 farnesyl binding pocket selectively inhibits Ras-GTP