◀ Back to EPO
EPAS1 — EPO
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Scortegagna et al., Blood 2005
(Anoxia...) :
HIF-2alpha regulates murine hematopoietic development in an
erythropoietin dependent manner
Chavez et al., J Neurosci 2006
(Hypoxia-Ischemia, Brain) :
In contrast, reduction of
HIF-2alpha expression by siHIF-2alpha
led to a drastic decrease of
EPO hypoxic expression, but it did not affect LDH or VEGF upregulation ... These results indicate that
HIF-2alpha mediates the transcriptional activation of
EPO expression in astrocytes, and this pathway may promote astrocytic paracrine dependent neuronal survival during ischemia
Rankin et al., J Clin Invest 2007
(Disease Models, Animal...) :
Furthermore, we found that physiological
Epo expression in infant livers
required Hif-2alpha but not Hif-1alpha and that the hypoxic induction of liver Epo in anemic adults was Hif-2alpha dependent
Nangaku et al., J Mol Med (Berl) 2007
(Anoxia...) :
HIF consists of a constitutive beta-subunit and one of alternative oxygen regulated HIF alpha-subunits ( HIF-1alpha, HIF-2alpha, and HIF-3alpha ), and
HIF-2alpha is
responsible for
erythropoietin production
Percy et al., N Engl J Med 2008
(Polycythemia) :
Our functional studies indicate that this mutation leads to stabilization of the HIF-2alpha protein and suggest that wild-type
HIF-2alpha regulates
erythropoietin production in adults
Yamashita et al., Blood 2008
(Anemia) :
Recent evidence has indicated that
erythropoietin (Epo) expression is
regulated by hypoxia-inducible transcription factors ( HIFs ),
HIF-2alpha in particular
Nangaku et al., Nephron. Experimental nephrology 2008
(Anoxia...) :
Intracellular accumulation of HIF induces the coordinated expression of a number of adaptive genes against hypoxic insult.Three isoforms of HIF-alpha subunits have been identified, HIF-1alpha, HIF-2alpha, and HIF-3alpha, of which
HIF-2alpha is
involved in the regulation of
erythropoietin as well as oxidative stress
Percy et al., Ulster Med J 2008
(Genetic Predisposition to Disease...) :
Furthermore,
HIF-2 alpha plays an important role in the regulation of
Epo production
De Spiegelaere et al., Mol Cell Biochem 2010
:
Moreover, the presence of both proteins at the same locations supports the hypothesis that
EPO expression is
regulated by
HIF-2alpha
Wang et al., PloS one 2010
(Anoxia) :
Hypoxia-inducible expression of the
erythropoietin (EPO) gene is
mediated principally by
hypoxia-inducible factor 2alpha ( HIF-2alpha ) in Hep3B cells under physiologic conditions