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EIF2AK2 — TAT

Text-mined interactions from Literome

Demarchi et al., J Virol 1999 : Here, we show that this activity of Tat requires the function of the cellular interferon-inducible protein kinase PKR ... Expression of a dominant negative mutant of PKR specifically reduced the levels of Tat transactivation in different human cell types
McMillan et al., Virology 1995 : Expression of Tat 72 in HeLa cells resulted in direct interaction with PKR as detected by coimmunprecipitation with a Tat antibody
Brand et al., J Biol Chem 1997 : Phosphorylation of Tat by PKR is dependent on the prior activation of PKR by dsRNA and occurs on serine and threonine residues adjacent to the basic region important for TAR RNA binding and Tat function