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ACTR3 — CDC42
Pathways - manually collected, often from reviews:
-
Reactome Reaction:
ACTR3
→
CDC42
(indirect_complex)
Rohatgi et al., Cell 1999, Takenawa et al., J Cell Sci 2001, Zalevsky et al., Curr Biol 2001
-
Reactome Reaction:
ACTR3
→
CDC42
(reaction)
Rohatgi et al., Cell 1999, Takenawa et al., J Cell Sci 2001, Zalevsky et al., Curr Biol 2001, Le Clainche et al., Proc Natl Acad Sci U S A 2003, Kovar et al., Nat Cell Biol 2006
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Fucini et al., Mol Biol Cell 2002
:
Actin recruitment involves
Cdc42/Rac and
requires the activation of the
Arp2/3 complex
Olazabal et al., Curr Biol 2002
:
Rac and
Cdc42 are
required for actin and
Arp2/3 complex recruitment during FcgammaR phagocytosis, while Rho controls actin assembly at CR phagosomes
Tang et al., J Biol Chem 2004
:
Cdc42 may
regulate the activation of neuronal Wiskott-Aldrich syndrome protein and the
actin related protein complex, which in turn regulate actin filament polymerization initiated by the contractile stimulation of smooth muscle
Lodge et al., Cell Microbiol 2005
:
The dominant negative
Cdc42N17 inhibited LPG mediated phagosomal accumulation of F-actin and retention of
Arp2/3 and Myosin
Shen et al., Eukaryotic cell 2012
:
In
response to intersectin ITSN1 and Rho GTPase
Cdc42 , WASP activates the
Arp2/3 complex to promote actin polymerization
Ma et al., Proc Natl Acad Sci U S A 1998
:
We propose that
activation of the
Arp2/3 complex by
Cdc42 and other signaling molecules plays a central role in stimulating actin polymerization at the cell surface