Ohtsu et al., Arterioscler Thromb Vasc Biol 2005
(Cardiovascular Diseases) :
We have further demonstrated that the Rho/ROCK activation by Ang II requires protein kinase C-delta (PKCdelta) and proline-rich tyrosine kinase 2 (PYK2) activation, but not epidermal growth factor receptor transactivation
Ying et al., Nan Fang Yi Ke Da Xue Xue Bao 2009
:
Ang1-7 can inhibit AngII induced activation of Rock2 and reduce alpha-SMA expression in HSCs
Li et al., Zhonghua Gan Zang Bing Za Zhi 2012
:
Ang ( 1-7 ) inhibited the Ang II-stimulated up-regulation of RhoA, ROCK , and CTGF ... Ang ( 1-7 ) can inhibit the Ang II-stimulated up-regulation of RhoA, ROCK and CTGF in hepatic stellate cells, indicating that the ACE2-Ang ( 1-7 ) -Mas axis, an important branch of the renin-Ang-aldosterone system is involved in the occurrence and development of liver fibrosis