◀ Back to ANG

ANG — NOX5

Text-mined interactions from Literome

Touyz et al., Circ Res 2002 : These novel findings provide insight into the molecular regulation of NAD ( P ) H oxidase by Ang II in HVSMCs
Harrison et al., J Renin Angiotensin Aldosterone Syst 2003 (Cardiovascular Diseases) : Studies of genetically altered mice have unequivocally shown that activation of the NAD ( P ) H oxidase by Ang II contributes to hypertension, LVH and atherosclerosis
Wu et al., Free Radic Biol Med 2004 (Intestinal Perforation...) : Sepsis ( i.e., cecal ligation and puncture (CLP) model ) elevated both plasma protein carbonyl ( i.e., an index of oxidative stress ) and plasma nitrite/nitrate ( NOx ) levels, reduced baseline mean arterial blood pressure ( MABP ), and inhibited the MABP pressor response to angiotensin II (Ang II) at 6 h post-CLP
Keller et al., Free radical research 2004 : Inhibition of the NADPH oxidase using gp91ds-tat prevented the Ang II-induced increase in DCF fluorescence, without affecting cells loaded with H2-calcein
Milovanova et al., Am J Physiol Cell Physiol 2006 (Ischemia) : ANG II activation of NADPH oxidase was unaffected by KATP gene deletion
Chan et al., Circ Res 2005 : These results suggest that NADPH oxidase derived O2*- underlies the activation of p38 MAPK or ERK1/2 by Ang II in the ventrolateral medulla
Schulman et al., J Hypertens Suppl 2006 (Atherosclerosis...) : In hypertensive Dahl salt-sensitive rats, a paradigm of human salt-sensitive hypertension, inhibition of Ang II type 1 receptor or NAD ( P ) H oxidase derived ROS prevented the development of endothelial dysfunction, upregulation of pro-atherogenic molecules, and vascular ROS generation, independently of blood pressure
Schupp et al., American journal of physiology. Renal physiology 2007 : There is evidence that ANG II is an activator of NAD ( P ) H oxidase , leading to the formation of free radicals, which are known to participate in the induction of DNA damage
Habibi et al., Endocrinology 2007 (Body Weight...) : Angiotensin-II (Ang-II) stimulated increases in nicotinamide adenine dinucleotide phosphate reduced ( NADPH ) oxidase activity and oxidative stress are known to play a key role in cardiac remodeling
An et al., Cardiovasc Res 2007 : Ang II-evoked expression of ET-1 in adventitial fibroblasts appears to be mediated , at least in part, by NADPH oxidase
Yang et al., Atherosclerosis 2008 : In the presence of angiotensin II (Ang II) , insulin stimulates NAD ( P ) H oxidase activity leading to increased VSMC migration
Zhang et al., Cardiovasc Res 2007 : Peptide hormone Angiotensin II (Ang II) activates NAD ( P ) H oxidase , via AT1 receptors leading to increased generation of reactive oxygen species ( ROS ), such as the superoxide anion ( O ( 2 ) ( - ) )
Roghair et al., Pediatr Res 2008 (Prenatal Exposure Delayed Effects) : NADPH oxidase dependent superoxide production plays an important role in both Ang II signaling and coronary disease
Fujimoto et al., Hypertens Res 2008 : Angiotensin II (Ang II) induces production of NAD ( P ) H oxidase dependent superoxide in vascular and mesangial cells, but the direct role of Ang II in glomerular superoxide production remains unknown ... These results indicate that Ang II directly induced superoxide production through activation of NAD ( P ) H oxidase , and olmesartan would inhibit superoxide production and oxidative stress independent of its blood pressure lowering effect
Carlström et al., Am J Physiol Regul Integr Comp Physiol 2009 (Disease Models, Animal...) : NOX2 can be activated by elevated ANG II and may play an important role in ANG II-induced hypertension
Oliveira-Sales et al., Am J Hypertens 2009 (Hypertension, Renovascular) : Based on previous data, we hypothesized that an increase of angiotensin II (Ang II)-via the Ang II type 1 (AT-1) receptor-in the rostral ventrolateral medulla ( RVLM ) and the paraventricular nucleus ( PVN ) of the hypothalamus could activate NAD ( P ) H oxidase that will produce superoxides resulting in increased sympathetic activity and hypertension
Montezano et al., Circ Res 2010 (Inflammation) : Ang II and ET-1 activated NADPH oxidase , an effect blocked by low [ Ca ( 2+ ) ] ( e ), but not by EHT1864
Peng et al., J Appl Physiol 2011 : ANG II, a peptide generated within the carotid body, is a potent activator of Nox2
Malik et al., Prostaglandins Other Lipid Mediat 2012 (Hypertension) : CYP1B1 is expressed in cardiovascular and renal tissues, and mediates angiotensin II (Ang II) induced activation of NADPH oxidase and generation of reactive oxygen species ( ROS ), and vascular smooth muscle cell migration, proliferation, and hypertrophy
Yousif et al., Pharmacol Res 2012 (Diabetes Mellitus, Experimental...) : Here, we studied the effects of chronically inhibiting endogenous Ang- ( 1-7 ) formation with DX600, a selective angiotensin converting enzyme-2 (ACE2) inhibitor, on renal and cardiac NADPH oxidase ( NOX ) activity, vascular reactivity and cardiac function in a model of Type-1 diabetes ... In conclusion, endogenous Ang- ( 1-7 ) inhibits diabetes induced cardiac/renal NOX activity and end-organ damage, and mediates the actions of Captopril and Losartan
Kim et al., PloS one 2012 : Angiotensin II (Ang II) induced activation of nicotinamide adenine dinucleotide phosphate ( NAD ( P ) H ) oxidase leads to increased production of reactive oxygen species ( ROS ), an important intracellular second messenger in renal disease
Jarajapu et al., Diabetes 2013 (Diabetes Mellitus) : Ang- ( 1-7 ) restored impaired migration and nitric oxide bioavailability/cGMP in response to stromal cell derived factor and resulted in a decrease in NADPH oxidase activity
Wang et al., Am J Physiol Regul Integr Comp Physiol 2013 (Hypertension) : These findings suggest that slow-pressor ANG II increases the association of NR1 with NOX2 in dendrites of PVN neurons, resulting in enhanced NOX derived ROS and reduced NO during glutamatergic activity