Peña-Llopis et al., EMBO J 2011
(MAP Kinase Signaling System) :
mTORC1 coordinately regulates TFEB phosphorylation and nuclear localization and in a manner dependent on both TFEB and V-ATPases, mTORC1 promotes endocytosis
Settembre et al., EMBO J 2012
:
Conversely, pharmacological inhibition of mTORC1 , as well as starvation and lysosomal disruption, activates TFEB by promoting its nuclear translocation
Martina et al., J Cell Biol 2013
:
Interaction of TFEB with active Rag heterodimers promoted recruitment of TFEB to lysosomes, leading to mTORC1 dependent phosphorylation and inhibition of TFEB