◀ Back to WNT1
SHH — WNT1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Treichel et al., Genes Dev 2003
:
We present evidence that mBtd is required during early limb development to maintain, but not to initiate
Wnt/beta-catenin dependent FGF,
Shh , and BMP mediated signaling
Robertson et al., Dev Dyn 2004
:
We demonstrate that activation of
Wnt signaling
results in an inhibition of the
Shh response in neural tissue
Lei et al., Dev Cell 2006
:
Here, we show that
Wnt pathway inhibitors
regulate the threshold response of a ventral
Shh target gene, Nkx2.2, to establish its restricted expression in the ventral spinal cord
Iwatsuki et al., Proc Natl Acad Sci U S A 2007
:
Exogenously added Shh suppressed expression of endogenous Shh and
inhibited Wnt/beta-catenin signaling ( assessed in TOPGAL mice ), further implicating
Shh as an inhibitor of the Wnt/beta-catenin pathway
Martinez-Ferre et al., J Neurosci 2013
:
Here we investigated a key
role of
Wnt signaling in the molecular regulation of ZLI positioning and
Shh expression, using experimental embryology in ovo in the chick