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Veenstra et al., J Immunol 2002
(Neoplasms) :
In contrast, IL-1alpha, IL-1beta,
TNF-alpha , IFN-gamma-inducible protein-10, and Th2 cytokines such as IL-4 and IL-10 did not
induce IL-18BPa
Kim et al., Cancer Lett 2003
:
In this study, we investigated the
effects of
BPA on the production of nitric oxide ( NO ) and
tumor necrosis factor-alpha (TNF-alpha) , and on the level of inducible nitric oxide synthase (iNOS) and TNF-alpha gene expression in mouse macrophages ...
BPA alone did not
affect NO or
TNF-alpha production ... In contrast,
BPA inhibited lipopolysaccharide (LPS) induced NO and
TNF-alpha production, and the levels of iNOS and TNF-alpha mRNA in a dose dependent manner
Benachour et al., Toxicol Appl Pharmacol 2009
:
We also showed that
BPA increased significantly the
tumor-necrosis factor alpha (TNF-alpha) gene expression and protein excretion as measured by real-time RT-PCR and ELISA luminescent test, respectively ... Moreover, we observed that induction of AK activation and
TNF-alpha gene expression
require lower levels of
BPA than apoptosis or TNF-alpha protein excretion
Marotte et al., Arthritis Rheum 2010
(Arthritis, Rheumatoid...) :
Evaluation of signaling pathways suggested that
TNFalpha induced IL-18 production through the ERK-1/2, protein kinase Cdelta (PKCdelta), and Src pathways, whereas
IL-18BPa synthesis was mediated through the NFkappaB, PKC, Src, and JNK pathways
Byun et al., Environ Toxicol Pharmacol 2005
:
We investigated the effects of BPA exposure on the activities of murine peritoneal macrophages through evaluation of
BPA induced alteration of nitric oxide ( NO ) production,
tumor necrosis factor-a (TNF-a) synthesis, and expression of co-stimulatory molecules B7 ... In vitro,
BPA suppressed
TNF-a secretion with significant reduction at 10 and 100µM BPA