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CTLA4 — TNF
Text-mined interactions from Literome
Chabot et al., J Immunol 1999
:
By also measuring TNF-alpha levels, specificity of cytokine regulation was observed ; while anti-CD40 and
CTLA-4-Fc reduced IL-10 and
TNF-alpha levels, anti-CD23 did not affect TNF-alpha while attenuating IL-10 generation
Gonzalo et al., J Immunol 2001
:
ICOS-Ig, but not
CTLA4-Ig , uniquely
regulates SAg induced
TNF-alpha production, whereas IL-2 secretion is modulated by CTLA4-Ig, but not ICOS-Ig
Chabot et al., J Neurosci Methods 2001
(Central Nervous System Diseases...) :
Morphological features and mechanisms of cytokine production resemble those observed in microglia -- T cell co-cultures since
CTLA-4 and CD40 -- CD40L blockades
reduce TNF-alpha and IL-10 levels, while anti-CD23 inhibits IL-10 only in U937 -- T cell interactions
Shao et al., Invest Ophthalmol Vis Sci 2001
(Autoimmune Diseases...) :
CTLA4-Fc inhibited the expansion of antigen-specific MAA-T cells and the production of
TNF-alpha
Vasu et al., Int Immunol 2003
(Thyroiditis, Autoimmune) :
Our data suggest that engagement of
CTLA-4 expressed on activated autoreactive T cells in close proximity to the thyroid can
increase the number of regulatory T cells and their ability to produce TGF-beta1, with a concomitant reduction in IFN-gamma and
TNF-alpha , resulting in suppression of EAT
Li et al., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2005
:
The
effect of expressed IkappaBalpha and
CTLA4Ig on the expression of
TNF-alpha of ECV304 cells stimulated with LPS was also investigated
Pandiyan et al., J Immunol 2007
(Inflammation) :
Indeed, production of the proinflammatory cytokine IFN-gamma, but not
TNF-alpha , by CD8 T cells was
inhibited by
CD152 engagement
Matsumoto et al., Arthritis Res Ther 2008
(Arthritis, Rheumatoid) :
Anti-TNF-alpha mAbs and
CTLA-4Ig suppressed
TNF-alpha production, whereas anti-IFN-gamma mAbs, anti-IL-12 mAbs, and CTLA-4 Ig inhibited IFN-gamma production
Laurent et al., Journal of translational medicine 2013
:
The engagement of
CTLA-4 on primary melanoma cell lines
induces antibody dependent cellular cytotoxicity and
TNF-a production