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BPI — TNF

Text-mined interactions from Literome

Zhou et al., Zhonghua Shao Shang Za Zhi 2001 : The abilities of porcine BPI to combine endotoxin ( lipopolysaccharide, LPS ) and inhibit the release of TNFalpha from hepatic Kupffer 's cells were examined ... The effects of the BPI on the inhibition of the release of TNFalpha from hepatic Kupffer 's cells were dose-dependant
Weiss et al., J Clin Invest 1992 : TNF release induced by K. pneumoniae and P. aeruginosa was also inhibited by both holo-BPI and fragment but, at the protein concentrations tested, P. aeruginosa was killed only by the fragment and K. pneumoniae was not killed by either protein
Marra et al., J Immunol 1992 (Fever) : For example, BPI blocks LPS stimulated TNF release in vitro and in vivo, and LPS complexed to BPI is not pyrogenic in rabbits
Jin et al., J Clin Invest 1995 (Hypotension...) : BPI treated immediately after LPS reduced the circulating levels of endotoxin and IL-6 but increased the circulating levels of TNF
Dentener et al., J Immunol 1993 : LBP was shown to enhance LPS induced TNF-alpha , IL-6, and IL-8 release by mononuclear phagocytic cells, whereas BPI inhibited the release of these cytokines
von der Möhlen et al., J Immunol 1996 (Shock, Septic) : To assess the role of TNF in the elevated BPI levels during sepsis, the following studies were performed ... These results suggest that TNF is not critical for the release of BPI from neutrophils during experimental endotoxemia or clinical sepsis
Jahr et al., Infect Immun 1997 : BPI was found to inhibit TNF production from monocytes stimulated with poly ( M ) in the presence of LBP, LBP-sCD14, or 10 % human serum ... Our data demonstrate a role for LBP, LBP-sCD14, and BPI in modulating TNF responses of defined polysaccharides