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NOS3 — TLR4

Text-mined interactions from Literome

Brightbill et al., Science 1999 : Several lipoproteins stimulated TLR dependent transcription of inducible nitric oxide synthase and the production of nitric oxide, a powerful microbicidal pathway
Suliman et al., FASEB J 2005 : In wild-type ( Wt ) mice injected with heat inactivated E. coli, hepatic TLR4 and TLR2 proteins were up-regulated with TLR dependent increases in transcript levels for tumor necrosis factor ( TNF-alpha ), interleukin 6, nitric oxide synthase-II ( iNOS ), and NADPH oxidase 2 (Nox2)
Masamune et al., J Gastroenterol 2008 : TLR ligands induced expression of monocyte chemoattractant protein 1, cytokine induced neutrophil chemoattractant 1 ( a rat homolog of interleukin-8 ), and inducible nitric oxide synthase , but not proliferation or type I collagen production
Yazji et al., Proc Natl Acad Sci U S A 2013 (Enterocolitis, Necrotizing) : Using a unique mouse system in which we selectively deleted TLR4 from the endothelium, we now show that endothelial TLR4 activation is required for NEC development and that endothelial TLR4 activation impairs intestinal perfusion without effects on other organs and reduces eNOS expression via activation of myeloid differentiation primary response gene 88