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HMOX1 — TLR4

Text-mined interactions from Literome

Song et al., World J Gastroenterol 2003 : TLR4 mediates LPS induced HO-1 expression in mouse liver : role of TNF-alpha and IL-1beta ... The effect of toll-like receptor-4 (TLR4) on LPS induced liver HO-1 expression and the role of TNF-alpha and IL-1beta in this condition were determined ... This study demonstrates that TLR4 plays a dominant role in mediating HO-1 expression following LPS
Shen et al., Am J Transplant 2005 (Reperfusion Injury) : Moreover, defective TLR4 but not TLR2 signaling increased mRNA/protein HO-1 expression ... CoPP induced HO-1 overexpression ameliorated hepatic damage in IRI-susceptible TLR2 KO mice, comparable with WT controls, and concomitantly diminished TLR4 levels
Chen et al., Chin J Traumatol 2008 (Acute Disease...) : TLR-4 and HO-1 might modulate the balance of pro- and anti-inflammatory processes in inflammatory reaction of hemorrhagic shock induced ALI, and the activation of Toll-like receptor might induce the transcription activity of HO-1 , which may play a key role in acute lung injury
Chen et al., Mol Biol Rep 2013 (Acute Lung Injury...) : Activation of TLR4 might induce HO-1 expression and HO-1 modulates proinflammatory responses that are triggered via TLR4 signaling