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TCF24 — WNT3A

Text-mined interactions from Literome

Takeda et al., J Biol Chem 2000 (Eye Abnormalities) : Induction of melanocyte-specific microphthalmia associated transcription factor by Wnt-3a
Oshita et al., Genes Cells 2003 : Furthermore, Daple inhibited Wnt-3a dependent activation of T-cell factor ( Tcf ) transcriptional activity
Koch et al., Clin Cancer Res 2005 (Hepatoblastoma...) : In human liver tumor cells without beta-catenin mutations, Nkd-1 inhibited the Wnt-3a activated Tcf-responsive-luciferase reporter activity, whereas Nkd-1 in hepatoblastomas with beta-catenin mutations had no antagonistic effect
Kiel et al., Bone 2007 : In vitro, TCF-Lef activity in presence of Wnt3a was significantly reduced in cells expressing LRP5 haplotypes carrying the T allele of exon 10 and 18 compared to the wild-type allele, whereas co-expression of Dkk1 completely inhibited Wnt3a response through all LRP5 haplotypes
Yokoyama et al., Journal of molecular signaling 2007 : Wnt3a action attenuates phosphoprotein phosphatase-2A activity and stimulates the Lef/Tcf-sensitive gene transcription
Shimizu et al., Mol Cell Biol 2008 : Moreover, we show that Wnt-3a activation of LEF/T-cell factor ( TCF ) -dependent transcription depends on beta-catenin but not on plakoglobin ... We also clearly demonstrate that plakoglobin is insufficient for LEF/TCF dependent transcriptional activation by Wnt-3a in F9 cells
Bikkavilli et al., J Cell Sci 2008 : Chemical inhibitors of p38 MAPK ( SB203580 or SB239063 ) and expression of a dominant negative-version of p38 MAPK attenuate Wnt3a induced accumulation of beta-catenin, Lef/Tcf-sensitive gene activation, and primitive endoderm formation
Haÿ et al., Mol Cell Biol 2009 : N-cadherin overexpression in osteoblasts increases N-cadherin-LRP5 interaction, causing increased beta-catenin degradation and altered TCF/LEF transcription in response to Wnt3a
Yokoyama et al., J Cell Sci 2009 : Treatment with either genistein or Src family kinase inhibitor PP2 attenuates Wnt3a stimulated Lef/Tcf transcription activation and primitive endoderm formation ... siRNA induced knockdown of Src likewise attenuates Lef/Tcf transcription and primitive endoderm formation in response to Wnt3a , implicating Src as a positive regulator of Wnt/beta-catenin signaling ... The Y18F mutant of Dvl2 attenuates the Wnt3a stimulated Lef/Tcf-sensitive transcriptional response
Finlayson et al., PloS one 2009 (Cell Transformation, Neoplastic...) : Consequently, knockdown of MRP in EpRas caused loss of tumorigenesis in vivo, and reduced Wnt3a induced TCF reporter signaling in vitro
Qiang et al., Br J Haematol 2010 (Multiple Myeloma) : Finally, Wnt3a induced TCF/LEF transcriptional activity suggests that canonical Wnt signalling is active in osteoclasts
Kang et al., PloS one 2010 (Colorectal Neoplasms...) : Wnt3a stimulated formation of the beta-catenin/TCF complexes to two functional TCF-4 binding elements within the PLD2 promoter as assessed by chromatin immunoprecipitation assay
Yokoyama et al., Journal of molecular signaling 2012 : Point mutations of phosphorylation sites of Dvl3 which interfere with Lef/Tcf-sensitive transcriptional activation by Wnt3a are shown to interfere more proximally with the assembly of Dvl3 based supermolecular complexes