◀ Back to PTGS2
PPARG — PTGS2
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
PPARG
→
PTGS2
(increases, PTGS2 Activity)
Evidence: The sentence (ResnetDB) An activator of peroxisome proliferator-activated receptor gamma, 15-deoxy-Delta(12,14)-prostaglandin J(2), also induces COX-2 expression and inhibits TNFalpha-induced NFkappaB activation and COX-2 expression. is translated to Activation of PTGS2 (Homo sapiens) Gene Expression by PPARG (Homo sapiens) Protein.
Text-mined interactions from Literome
Subbaramaiah et al., J Biol Chem 2001
(Arthritis...) :
PMA mediated induction of
COX-2 promoter activity was
inhibited by
PPARgamma ligands ; this suppressive effect was prevented by overexpressing a dominant negative form of PPARgamma or a PPAR response element decoy oligonucleotide
Nixon et al., Prostaglandins Leukot Essent Fatty Acids 2003
(Colorectal Neoplasms) :
In general, however, neither COX-1- nor
COX-2-specific inhibitors
induced the activation of
PPARgamma
Li et al., World J Gastroenterol 2003
(Carcinoma, Hepatocellular...) :
PPARgamma pathway activation
results in apoptosis and
COX-2 inhibition in HepG2 cells
Mendez et al., Hypertension 2003
:
PPARgamma inhibition of
cyclooxygenase-2 , PGE2 synthase, and inducible nitric oxide synthase in cardiac myocytes
Han et al., Clin Cancer Res 2003
(Uterine Cervical Neoplasms) :
We used transient transfection assays with COX-2 promoter reporter gene constructs to determine the regulatory sites in this promoter, which mediates
PPARgamma regulation of
COX-2 activity ... Using CaSki cells, we demonstrated that
COX-2 and PPARgamma mRNA levels were inversely
regulated by
PPARgamma ligands in that these compounds up-regulated PPARgamma but down-regulated COX-2 ... The ability of
PPARgamma ligands to
inhibit COX-2 appears to be mediated predominantly through inhibition of AP-1 protein binding to the CRE site in the COX-2 promoter
Badawi et al., Cancer Res 2004
(Mammary Neoplasms, Experimental) :
COX-2 inhibitors and PPAR gamma agonists coordinately mediate their anticancer effect via both COX dependent ( inhibition of
COX-2 ,
activation of
PPAR gamma , and modulation PG synthesis ) and COX independent ( induction of proapoptotic factors and inhibition of cell proliferation ) pathways
Sakamoto et al., Br J Cancer 2004
(Adenocarcinoma...) :
From these results, it was suggested that
PPARgamma activation might
suppress COX-2 expression via the nuclear factor-kappaB pathway in the ovarian carcinoma cells and that low expression of PPARgamma and high expression of COX-2 might be involved in carcinogenesis and progression of ovarian tumours
Pawliczak et al., J Biol Chem 2004
:
It has been reported that interleukin-8 (IL-8) and
cyclooxygenase-2 (COX-2) expression is
regulated by peroxisome proliferator activated receptor (
PPAR)-gamma synthetic ligands
Sabichi et al., Cancer Epidemiol Biomarkers Prev 2004
:
However, forced expression of
PPAR-gamma1 or PPAR-gamma2 in ECs
suppressed the high level of endogenous
COX-2
Delage et al., Int J Cancer 2005
:
HLD consumption
induced early downregulation of
PPARgamma ( -33.1 % ) and RARbeta ( -53.1 % ) mRNA expression concomitant with an increase in levels of
COX-2 ( +45.5 % ) and beta-catenin ( +84.56 % ) and in the number of ACF ( 191.56 +/- 88.60 vs. 21.14 +/- 11.64, p < 0.05 )
Patel et al., Cell Signal 2005
:
This work investigates the
effects of
PPAR(gamma) ligands on the regulation of
cyclooxygenase-2 (COX-2) in the human lung epithelial cell line, A549
Sato et al., Shock 2005
(Inflammation...) :
Inhibition of
COX-2 by NS-398 ( 30 mg/kg, but not 3 or 10 mg/kg ) not only reversed the deleterious effects of COX-2, but additionally
induced expression and nuclear translocation of
PPARgamma
Yu et al., Hepatology 2006
(Liver Neoplasms...) :
Troglitazone mediated
PPARgamma activation also
suppressed COX-2 expression and induced p27 in HCC cells
Zhang et al., J Invest Dermatol 2006
:
We therefore reasoned that PPARgamma activation and
PPARgamma dependent
COX-2 expression may occur as a general consequence of oxidative stress
Zhang et al., Int Immunopharmacol 2006
(Colitis...) :
Treatment with Dex improved
PPARgamma expression and
inhibited the expression of
COX-2 , 15d-PGJ ( 2 ) and PGE ( 2 )
Ptasinska et al., FASEB J 2007
:
NO* mediated
PPARgamma binding and NO*
induction of
cyclooxygenase-2 (COX-2) , diacylglycerol (DAG) kinase alpha ( DGKalpha ), and heme oxygenase-1 (HO-1), genes with well characterized PPRE motifs, were cGMP independent
ChĂȘne et al., Biochim Biophys Acta 2007
:
These findings demonstrate that n-3 and n-6 PUFA increased
PPARgamma activity is
necessary for the
COX-2 induction in HaCaT human keratinocyte cells
Xin et al., Cancer 2007
(Ascites...) :
It was recently reported that high expression of peroxisome proliferator activated receptor gamma ( PPARgamma ) and low expression of cyclooxygenase-2 (COX-2) might be involved in the inhibition of ovarian tumor progression and confirmed that
PPARgamma activation could
suppress COX-2 expression via the nuclear factor-kappaB pathway in ovarian cancer cells
Bren-Mattison et al., Mol Pharmacol 2008
(Adenocarcinoma...) :
Increased
PPARgamma inhibited expression of
COX-2 protein and promoter activity, resulting in decreased PGE ( 2 ) production
Taketa et al., J Biol Chem 2008
(Atherosclerosis...) :
Ox-LDL transiently induced cyclooxygenase-2 (COX-2) mRNA and protein expression, and COX-2 specific inhibition by NS-398 or meloxicam or small interference RNA of
COX-2 suppressed Ox-LDL induced PPARalpha and
PPARgamma activation
Ulivi et al., J Cell Physiol 2008
(Inflammation) :
( 4 ) p38 is involved in the
PPARgamma mediated
induction of
COX-2
Mustafa et al., Clin Cancer Res 2008
(Adenocarcinoma...) :
Both inhibition of
COX-2 and
activation of
PPARgamma can inhibit proliferation of breast cancer cells in vitro
Zhang et al., World J Gastroenterol 2009
(Disease Progression...) :
Furthermore,
COX-2 inhibition
resulted in the up-regulation of
PPARgamma expression, a protective molecule with anti-neoplastic effects
Hotta et al., J Lipid Res 2010
:
PPARgamma dependent suppression of
COX-2 promoter activity was observed in response to carvacrol treatment
Hossain et al., Journal of bioscience and bioengineering 2010
(Mechanotransduction, Cellular) :
Compressive force inhibits adipogenesis through
COX-2 mediated down-regulation of
PPARgamma2 and C/EBPalpha ... In conclusion, compressive force inhibited adipogenesis by suppressing expression of
PPARgamma2 and C/EBPalpha in a
COX-2 dependent manner
Konger et al., PPAR research 2010
:
Importantly,
PPARgamma agonist
induced COX-2 expression and PGE ( 2 ) production were partially inhibited by the PPARgamma antagonist, GW9662, indicating that both PPARgamma dependent and -independent pathways are likely involved
Rajaram et al., J Immunol 2010
:
When activated,
PPARgamma promotes IL-8 and
cyclooxygenase 2 expression, a process modulated by a PPARgamma agonist or antagonist