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PIK3CA — PSEN1
Text-mined interactions from Literome
Baki et al., EMBO J 2004
(Alzheimer Disease...) :
PS1 activates
PI3K thus inhibiting GSK-3 activity and tau overphosphorylation : effects of FAD mutations ... Furthermore, conditions that inhibit this association prevent the
PS1 induced
PI3K/Akt activation , indicating that PS1 stimulates PI3K/Akt signaling by promoting cadherin/PI3K association ... PS1 FAD mutations inhibit the
PS1 dependent
PI3K/Akt activation, thus promoting GSK-3 activity and tau overphosphorylation at AD-related residues
Baki et al., J Neurosci 2008
(Alzheimer Disease...) :
Expression of exogenous WT
PS1 or constitutively active Akt in PS1-/- neurons
stimulates PI3K signaling and suppresses both caspase-3 activity and dendrite retraction