Qin et al., Hepatology 2008
(Diabetes Complications...) :
GW0742 and PPARdelta overexpression in hepatocytes induced the expression of insulin induced gene-1 (Insig-1) , an endoplasmic reticulum protein braking SREBP activation, at both the mRNA and the protein levels
Ravnskjaer et al., J Lipid Res 2010
:
Activation of PPARdelta increases the fatty acid oxidation capacity in INS-1E beta-cells, enhances glucose stimulated insulin secretion ( GSIS ) from islets, and protects GSIS against adverse effects of prolonged fatty acid exposure