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FOXO4 — PIK3CA
Text-mined interactions from Literome
Reagan-Shaw et al., Cancer Res 2006
(Breast Neoplasms...) :
Further, our data showed that
PI3K knockdown
resulted in a significant activation of
FoxO ; interestingly, a simultaneous knockdown of FoxO1a rescued the cells from apoptosis
Lavery et al., J Neurosci 2007
:
Our results raise the possibility that neurofibroma formation in individuals with neurofibromatosis might result in part from a
Ras-PI3K-Akt dependent inhibition of
FOXO within Schwann cells
Howlett et al., PLoS Genet 2008
:
In humans, PI3K and group II mGluRs are implicated in epilepsy, neurofibromatosis, autism, schizophrenia, and other neurological disorders ; however, neither the link between group II mGluRs and PI3K, nor the role of
PI3K dependent regulation of
Foxo in the control of neuronal excitability, had been previously reported
Park et al., Cell Signal 2009
:
In this study, we found that TRAIL inhibited
PI3K/Akt dependent
FoxO phosphorylation and relocated FoxO proteins into the nucleus from the cytosol in activated human hepatic stellate LX-2 cells
Mahajan et al., Thromb Haemost 2012
:
In conclusion, thrombin and FoxO factors functionally interact through
PI3K/Akt dependent
FoxO phosphorylation leading to expression of cell cycle regulating genes and ultimately SMC proliferation