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PARG — PARP2

Text-mined interactions from Literome

Woon et al., Curr Med Chem 2005 : Fifthly, PARP activity can be inhibited in cells by inhibition of poly(ADP-ribose)-glycohydrolase ( PARG ) ; will this be a viable strategy for future drug design ?
Botta et al., Biochemistry 2010 : The presence of the REG/MTS raises the possibility that PARG activity is regulated by interactions of PARP-1 and -2 and other proteins at this site, raises interesting questions concerning mitochondrial PARG because MTS residues are often removed after transport, and offers a potentially novel site for drug targeting of PARG
Grady et al., J Virol 2012 (Herpes Simplex) : This work demonstrates that HSV-1 infection results in changes to NAD ( + ) metabolism by PARP-1/2 and PARG, and as PAR chain accumulation can induce caspase independent apoptosis, we speculate that the decrease in PARG levels enhances the auto-PARylation mediated inhibition of PARP , thereby avoiding premature death of the infected cell