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MMP13 — OSM

Text-mined interactions from Literome

Hui et al., Ann Rheum Dis 2001 : IGF1 can also down regulate IL1alpha or IL1alpha + OSM induced MMP-1, MMP-3, MMP-8, and MMP-13 mRNA expression in human articular chondrocytes and bovine chondrocytes
Li et al., J Immunol 2001 : We have previously shown that OSM induces MMP and tissue inhibitor of metalloproteinase-3 ( TIMP-3 ) gene expression in chondrocytes by protein tyrosine kinase dependent mechanisms ... In the present study, we investigated signaling pathways regulating the induction of MMP and TIMP-3 genes by OSM ... Curcumin also inhibited OSM induced MMP-1, MMP-3 , MMP-13, and TIMP-3 gene expression ... Thus, OSM induces MMP and TIMP-3 genes in chondrocytes by activating JAK/STAT and mitogen activated protein kinase signaling cascades, and interference with these pathways may be a useful approach to block the catabolic actions of OSM
Hui et al., Arthritis Rheum 2003 (Osteoarthritis, Knee) : The in vivo data clearly indicated that OSM + TNFalpha overexpression increased MMP levels and decreased levels of tissue inhibitor of metalloproteinases 1 ( TIMP-1 ) ... Specifically, OSM + TNFalpha induced marked synovial hyperplasia, inflammation, and cartilage and bone destruction with a concomitant increase in MMP expression in both cartilage and synovium and decreased TIMP-1 expression in the articular cartilage
Sondergaard et al., Osteoarthritis Cartilage 2006 : TNF-alpha and OSM induced a pronounced increase in matrix metalloproteinase ( MMP ) activity, which was strongly inhibited by calcitonin
Fearon et al., Arthritis Rheum 2006 (Arthritis, Rheumatoid...) : OSM potentiated IL-1beta induced MMP-1 and MMP-13 expression in normal human cartilage/RASF cocultures, resulting in a significant increase in the MMP : TIMP ratio
El Mabrouk et al., Biochim Biophys Acta 2007 : OSM , alone or with Interleukin-1 ( IL-1beta ), increased glycosaminoglycan release and induced ADAMTS-4 and MMP-13 protein expression in human cartilage explants ... OSM dose- and time-dependently increased ADAMTS-4 mRNA and MMP-13 protein expression in human femoral head chondrocytes ... Parthenolide, a signal transducer and activator of transcription ( STAT1 and STAT3 ) phosphorylation inhibitor, reduced OSM induced ADAMTS-4 and MMP-13 gene expression and prevented STAT1/3 DNA binding activity ... These results suggest that OSM stimulated ADAMTS-4 and MMP-13 expression is mediated by ERK1/2, JAK3/STAT1/3 and PI3K/Akt and by cross talk between these pathways
Tiffen et al., Mol Endocrinol 2008 : OSM also promoted the expression of metalloproteinases MMP3, MMP12 , and MMP14, which, in vitro, were responsible for OSM-specific apoptosis
Litherland et al., J Biol Chem 2010 : However, MMP1 and MMP13 induction by IL-1 + OSM was inhibited only by aPKC silencing, suggesting that only atypical isoforms play a significant role in complex inflammatory milieus ... However, MMP1 and MMP13 induction by IL-1 + OSM was inhibited only by aPKC silencing, suggesting that only atypical isoforms play a significant role in complex inflammatory milieus